Clinical Report: Investigating the Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Insomnia in Post-Stroke Patients
Background
Post-stroke insomnia is a prevalent complication affecting over 50% of stroke survivors, significantly impacting their recovery and quality of life. Current treatment options, including sedative-hypnotics and cognitive behavioral therapy, have limitations. taVNS has shown potential in treating insomnia and related conditions, but evidence specifically for post-stroke insomnia is limited.
Data Highlights
This study will enroll 48 patients with post-stroke insomnia, randomly assigned to either a taVNS or sham-taVNS group, with interventions administered daily for four weeks. Primary outcomes include MRI indicators such as resting-state functional MRI and cerebral blood flow. Secondary outcomes involve clinical efficacy scales like the Pittsburgh Sleep Quality Index and the Hamilton Depression Rating Scale, assessed at multiple time points.
Key Findings
Post-stroke insomnia affects approximately 50% of stroke survivors.
Current treatments for insomnia in stroke patients have limitations, including risks of tolerance and dependence.
taVNS has demonstrated potential in treating insomnia and post-stroke depression.
This trial aims to provide evidence for the efficacy of taVNS in treating post-stroke insomnia.
Multimodal MRI will be used to assess changes in brain function and structure.
Clinical Implications
The findings from this trial may inform the clinical application of taVNS for managing insomnia in post-stroke patients.
Conclusion
This study seeks to address the evidence gap regarding the use of taVNS for post-stroke insomnia.
