A literature review: progress in the study of plastic bronchitis - Report - MDSpire

A literature review: progress in the study of plastic bronchitis

  • By

  • Huihan Li

  • Chi Han

  • Danchen Wu

  • Yuanyuan Zhang

  • May 4, 2026

  • 0 min

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Clinical Report: Advancements in Research on Plastic Bronchitis

Overview

This literature review synthesizes current evidence on plastic bronchitis (PB), emphasizing its recognition as a potentially life-threatening condition in pediatric populations. It highlights recent advances in diagnostic imaging, interventional bronchoscopy, and emerging pharmacological therapies.

Background

Plastic bronchitis is characterized by the formation of branching casts in the airways, leading to severe respiratory complications. The condition has a prevalence of approximately 6.8 per 100,000 in pediatric populations and is often associated with congenital heart disease. Increased awareness and improved management strategies are crucial for pediatric practitioners to address this serious condition effectively.

Data Highlights

No numerical data available in the article.

Key Findings

  • Plastic bronchitis is associated with significant morbidity and mortality in pediatric patients.
  • Recent advances in diagnostic imaging have improved the identification of PB.
  • Interventional bronchoscopy techniques are becoming essential for managing airway obstructions caused by PB.
  • Emerging pharmacological therapies show promise in treating PB effectively.
  • Awareness among general pediatricians regarding PB remains insufficient despite increasing case reports.

Clinical Implications

Pediatric practitioners should enhance their awareness of plastic bronchitis and its serious implications. The integration of advanced diagnostic and therapeutic techniques can significantly improve patient outcomes in those affected by this condition.

Conclusion

The review underscores the importance of ongoing research and clinical awareness in managing plastic bronchitis, particularly in pediatric populations. Enhanced diagnostic and therapeutic strategies are essential for improving care.

References

  1. Frontiers in Medicine, 2026 -- Case Report: Adult fibrinous bronchitis associated with lymphatic reflux: a probable diagnosis based on convergent evidence
  2. European Radiology, 2023 -- Pulmonary Imaging Findings in Adult Patients with Primary Immunodeficiency Disorders: A Comprehensive Review
  3. Bone Marrow Transplantation, 2011 -- Understanding the Known and Unknown Aspects of Bronchiolitis Obliterans Syndrome
  4. Evaluation and Management of the Child and Adult With Fontan Circulation: A Scientific Statement From the American Heart Association - PubMed
  5. Study Details | NCT02315898 | Inhaled Tissue Plasminogen Activator for Acute Plastic Bronchitis | ClinicalTrials.gov
  6. conexiant — Airway Resistome Higher In Chronic Lung Disease
  7. Evaluation and Management of the Child and Adult With Fontan Circulation: A Scientific Statement From the American Heart Association - PubMed
  8. Study Details | NCT02315898 | Inhaled Tissue Plasminogen Activator for Acute Plastic Bronchitis | ClinicalTrials.gov
  9. Fibrin IS present in plastic bronchitis casts and can impact treatment! - PubMed

Original Source(s)

A literature review: progress in the study of plastic bronchitis

  • by Huihan Li, Chi Han, Danchen Wu, Yuanyuan Zhang

  • May 4, 2026

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