Optimized deep learning ensemble using Fast Osprey algorithm for accurate lymphoblastic leukemia detection - Report - MDSpire

Optimized deep learning ensemble using Fast Osprey algorithm for accurate lymphoblastic leukemia detection

  • By

  • Narinder Kaur

  • Shakir Khan

  • Bobbinpreet Kaur

  • Amal Alomran

  • Sultan Ahmad

  • Thamer Alshammari

  • Fahad Omar Alomary

  • May 1, 2026

  • 0 min

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Clinical Report: Enhanced Deep Learning Ensemble for Lymphoblastic Leukemia Detection

Overview

The FOO-Ensemble framework demonstrates superior accuracy and efficiency in detecting Acute Lymphoblastic Leukemia (ALL) compared to traditional methods. With an accuracy of 97.76%, this novel approach significantly enhances diagnostic reliability and reduces inference time.

Background

Acute Lymphoblastic Leukemia (ALL) is a critical hematological malignancy that requires rapid and accurate diagnosis to improve patient outcomes. Traditional diagnostic methods are often labor-intensive and subject to observer variability, highlighting the need for advanced diagnostic tools. The integration of deep learning techniques offers a promising solution to enhance the precision and efficiency of ALL detection.

Data Highlights

MetricValue
Accuracy97.76%
Precision98.13%
Recall97.71%
F1-score97.83%

Key Findings

  • The FOO-Ensemble framework achieved an accuracy of 97.76% in ALL detection.
  • Precision was recorded at 98.13%, indicating high reliability in positive identifications.
  • The recall rate of 97.71% reflects the model's effectiveness in identifying true positives.
  • The F1-score of 97.83% demonstrates a balance between precision and recall.
  • Inference time was reduced compared to standalone models, enhancing clinical workflow.

Clinical Implications

The FOO-Ensemble framework provides a scalable and reliable tool for hematopathologists, potentially improving the speed and accuracy of ALL diagnoses. Its implementation could lead to better patient management and treatment outcomes through timely and precise identification of the disease.

Conclusion

The study underscores the potential of deep learning ensembles, particularly when combined with bio-inspired optimization techniques, to enhance diagnostic processes in Acute Lymphoblastic Leukemia. This innovative approach may significantly impact clinical practices and patient care.

References

  1. ASH CPG ALL Frontline Visual Summary 1217, American Society of Hematology, 2026 -- Guidelines for ALL Management
  2. AI-Based Imaging Model Predicts Extranodal Extension Burden and Improves Risk Stratification in Oropharyngeal Cancer, ASCO AI, 2026 -- AI in Oncology
  3. Detection of Contrast-Enhanced Breast Lesions in Rapid Screening MRI Utilizing Deep Learning Techniques, European Radiology, 2023 -- Deep Learning in Imaging
  4. the asco post — AI-Based Imaging Model Predicts Extranodal Extension Burden and Improves Risk Stratification in Oropharyngeal Cancer
  5. Deep Learning Approaches for Automated Image Segmentation and Evaluation of Treatment Outcomes in Metastatic Ovarian Cancer
  6. ASH CPG ALL Frontline Visual Summary 1217
  7. Clinical Review - Blinatumomab (Blincyto) - NCBI Bookshelf
  8. Toxicity of Brexucabtagene Autoleucel as a Standard Therapy for Adults with Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia - ScienceDirect

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