Blomia tropicalis allergens induce lung DNA methylation changes in neuroimmune genes in a mouse model of airway inflammation - Report - MDSpire

Blomia tropicalis allergens induce lung DNA methylation changes in neuroimmune genes in a mouse model of airway inflammation

  • By

  • Kevin Llinás-Caballero

  • Nathalie Acevedo

  • Simon Kebede Merid

  • Karen Donado

  • Hector Espinoza

  • Ernesto Mondol

  • Randy Reina

  • Ronald Regino

  • Inés Benedetti

  • Josefina Zakzuk

  • Leonardo Puerta

  • Erik Melén

  • Luis Caraballo

  • July 2, 2026

  • 0 min

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Allergens from Blomia tropicalis Cause Alterations in Lung DNA Methylation

Overview

This study explores the epigenetic effects of Blomia tropicalis allergens on lung DNA methylation in a mouse model of airway inflammation. Significant alterations in DNA methylation profiles were observed in genes related to neuroimmune functions and allergic responses.

Background

Blomia tropicalis is a significant allergen associated with allergic asthma, particularly in tropical regions. This study aims to investigate the specific DNA methylation changes induced by this house dust mite.

Data Highlights

AllergenNumber of DMRs
Blo t 2137
Blo t 13179
B. tropicalis extract313

Key Findings

  • Distinct lung DNA methylation profiles were observed in allergen-exposed mice compared to controls.
  • A total of 313 differentially methylated regions (DMRs) were identified in mice exposed to B. tropicalis extract.
  • Key genes affected included protocadherin alpha genes, cadherin 8, and interleukin 11 receptor alpha.
  • DMRs were enriched in biological processes related to cell adhesion and nervous system development.
  • Significant differences in mRNA levels of neuronal growth genes were noted, including Gdf7 and Bcl2l11.

Clinical Implications

The findings suggest that exposure to B. tropicalis allergens may lead to epigenetic changes that affect lung function and immune responses in allergic asthma. Understanding these mechanisms could inform future therapeutic strategies targeting epigenetic modifications in asthma management.

Conclusion

The study provides insights into the epigenetic alterations caused by B. tropicalis allergens.

Related Resources & Content

  1. Archives of Toxicology, 2021 -- Innate-like B-1 lymphocytes in mice enhance granuloma formation and inflammation triggered by inhaled particles in collaboration with macrophages
  2. Archives of Toxicology, 2015 -- Extracellular β-glucuronidase Linked to Inflammation Modifies Cellular Reactions to the Carcinogen Benzo[a]pyrene
  3. the analytical scientist, 2026 -- Mass Spec Roundup: From Alzheimer’s to Antarctic Dust
  4. Archives of Toxicology, 2024 -- Inhalation of Renewable Diesel Exhaust Particles Modifies Protein Levels and Toxicity Indicators in Bronchoalveolar Lavage Fluid and Plasma of Mice
  5. 2026 GINA Strategy Report - Global Initiative for Asthma - GINA
  6. SQ House Dust Mite Sublingual Immunotherapy Tablet in Children With Allergic Asthma: A Randomised Phase III Trial - PMC
  7. Integrative analysis identifies gene signatures mediating the effect of DNA methylation on asthma severity and lung function - PubMed
  8. 2026 GINA Strategy Report - Global Initiative for Asthma - GINA
  9. SQ House Dust Mite Sublingual Immunotherapy Tablet in Children With Allergic Asthma: A Randomised Phase III Trial - PMC
  10. Integrative analysis identifies gene signatures mediating the effect of DNA methylation on asthma severity and lung function - PubMed

Original Source(s)

Blomia tropicalis allergens induce lung DNA methylation changes in neuroimmune genes in a mouse model of airway inflammation

  • by Kevin Llinás-Caballero, Nathalie Acevedo, Simon Kebede Merid, Karen Donado, Hector Espinoza, Ernesto Mondol, Randy Reina, Ronald Regino, Inés Benedetti, Josefina Zakzuk, Leonardo Puerta, Erik Melén, Luis Caraballo

  • July 2, 2026

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