Clinical Report: Evaluation of Consistency in Quantitative Indocyanine Green Fluorescence Angiography

Overview

This study evaluates the reproducibility of quantitative indocyanine green fluorescence angiography (Q-ICG-FA) parameters across two software platforms. Key findings indicate varying levels of agreement for time-to-peak and normalized mean slope inflow, while other parameters showed poor to moderate agreement.

Background

Indocyanine green fluorescence angiography (ICG-FA) is increasingly used for intraoperative perfusion assessment in reconstructive surgery. Traditional qualitative assessments are subjective and can lead to variability in clinical outcomes, as noted in previous studies. Quantitative methods aim to provide objective metrics for perfusion evaluation, but consistency across software platforms remains uncertain.

Data Highlights

Key Findings

• Excellent agreement for TTP (ICC = 0.979).
• Normalized mean slope inflow showed high agreement (ICC = 0.944).
• Good to excellent agreement for T0, Fmax, and absolute mean slope inflow.
• Poor to moderate agreement for normalized maximum slopes.
• AMS showed higher TTP values compared to EPA (p < 0.001).
• Significant systematic differences were found for six out of seven parameters.

Clinical Implications

Clinicians should be aware of the variability in parameters when using different software platforms.

Conclusion

The study highlights the importance of evaluating Q-ICG-FA parameters across software platforms.

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