Unveiling a J-shaped association between the triglyceride-glucose index and in-hospital major adverse cardiovascular events in patients with acute myocardial infarction: a retrospective cohort study of 1,065 patients - Report - MDSpire
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Unveiling a J-shaped association between the triglyceride-glucose index and in-hospital major adverse cardiovascular events in patients with acute myocardial infarction: a retrospective cohort study of 1,065 patients
Clinical Report: J-shaped Relationship Between TyG Index and MACE in AMI
Overview
This study investigates the J-shaped relationship between the triglyceride-glucose (TyG) index and in-hospital major adverse cardiovascular events (MACE) in acute myocardial infarction (AMI) patients. It identifies an inflection point at a TyG index of 9.05, beyond which the risk of MACE significantly increases.
Background
Understanding the relationship between the TyG index and cardiovascular events is crucial for risk stratification in AMI patients.
Data Highlights
Group
Number of Patients
Incidence of MACE
T1 (Low)
352
16.76%
T2 (Medium)
361
26.04%
T3 (High)
352
21.13%
Key Findings
The overall incidence of in-hospital MACE was 21.13% among the 1,065 AMI patients studied.
The T2 group had a significantly higher incidence of MACE (26.04%) compared to the T1 group (16.76%, p = 0.011).
The T2 group was associated with a 178% increased risk of in-hospital MACE compared to the T1 group (OR = 2.78, p = 0.004).
A J-shaped relationship was identified, with an inflection point at a TyG index of 9.05.
For TyG index values <9.05, MACE risk did not change significantly (OR = 1.04, p = 0.875).
For TyG index values ≥9.05, MACE risk increased by 124% for each 1-unit increase (OR = 2.24, p = 0.006).
Clinical Implications
The findings indicate that the TyG index has a nonlinear relationship with MACE risk.
Conclusion
This study highlights the J-shaped relationship between the TyG index and MACE risk in AMI patients.
