The future and digital transformation of hypertension care: results from the ESH CARE app trial - Report - MDSpire

The future and digital transformation of hypertension care: results from the ESH CARE app trial

  • By

  • Laura M Ortega-Aviles

  • Betsy J Medina-Inojosa

  • Jose R Medina-Inojosa

  • September 5, 2025

  • 0 min

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Clinical Report: ESH CARE App Enhances Hypertension Control via Digital Innovation

Overview

A randomized trial demonstrated that use of the ESH CARE smartphone application significantly improved blood pressure control in adults with uncontrolled hypertension compared to usual care. At 6 months, 78% of app users achieved ambulatory BP targets versus 50% in the control group, highlighting the potential of digital tools to enhance hypertension management.

Background

Hypertension affects 1.3 billion people globally and remains the leading cardiovascular risk factor, contributing to approximately 10 million deaths annually. Despite advances in pharmacotherapy, population-level blood pressure control remains suboptimal, with less than one in four patients achieving target BP levels. Barriers such as therapeutic inertia, health literacy, and access limitations contribute to poor control, especially in at-risk populations. Digital interventions, including smartphone apps, offer scalable solutions to improve adherence, self-monitoring, and patient engagement.

Data Highlights

OutcomeESH CARE App GroupUsual Care GroupAbsolute Difference
Ambulatory BP Control (<130/80 mmHg)78%50%28%
Office BP Control (<140/90 mmHg)82%60%22%
BP Reduction (Systolic and Diastolic)Greater reductions observedSmaller reductionsNot specified numerically

Key Findings

  • 78% of participants using the ESH CARE App achieved ambulatory BP targets at 6 months versus 50% with usual care.
  • Office BP control was higher in the app group (82%) compared to usual care (60%).
  • The app group experienced larger reductions in both systolic and diastolic blood pressure.
  • Digital self-monitoring and remote coaching likely improved medication adherence and patient engagement.
  • The randomized design supports causal inference, though the study was limited by modest sample size, single-center setting, and short follow-up.
  • Exclusion of patients with established cardiovascular disease limits applicability to secondary prevention populations.

Clinical Implications

Incorporating smartphone-based applications like the ESH CARE App into hypertension management can enhance blood pressure control by facilitating regular self-monitoring, timely feedback, and improved adherence. Clinicians should consider digital tools as adjuncts to traditional care, especially in settings where remote monitoring can overcome access barriers. Further research is needed to optimize long-term engagement strategies and assess applicability in diverse and higher-risk populations.

Conclusion

The ESH CARE App study provides compelling evidence that digital innovation can significantly improve hypertension control, representing a promising avenue to bridge existing care gaps. Scaling such interventions may contribute to reducing the global cardiovascular disease burden.

References

  1. Konstantinidis et al. 2023 -- Targeting better hypertension control with the usage of the ESH smartphone application

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