Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease - Report - MDSpire

Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease

  • By

  • Mike Seed

  • Dawn Ilardi

  • Valerie Rofeberg

  • Cynthia Ortinau

  • Caren Goldberg

  • Garrett Reichle

  • Lauren Bush

  • Justin Elhoff

  • Amy Jo Lisanti

  • Jennifer Butcher

  • Caitlin Rollins

  • Andrew Van Bergen

  • Shabnam Peyvandi

  • Emily Bucholz

  • Stephanie Cox

  • Lyla Hampton

  • Jacqueline Sanz

  • Sonia Monteiro

  • Shruti Tewar

  • Kiona Allen

  • Caroline Lee

  • Kristi Glotzbach

  • Nneka Alexander

  • Laurel Bear

  • Corinne Anton

  • Renee Sananes

  • Linh Ly

  • Gina Boucher

  • Kelly Wolfe

  • Lindsay Edwards

  • Elizabeth Willen

  • Alexander Tan

  • Christina Ortega

  • Erica Sood

  • Anjali Sadhwani

  • Kari Crawford Plant

  • Lauren Quigley

  • Jessica Pliego

  • Elizabeth Valles

  • Abbey Hines

  • David Wypij

  • Thomas Miller

  • June 1, 2026

  • 0 min

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Clinical Report: Initial Neurodevelopmental Results in Pediatric Patients with Congenital Heart Disease

Overview

This study evaluates neurodevelopmental outcomes in infants and toddlers with congenital heart disease (CHD) following surgical repair. It identifies medical risk factors and social determinants associated with neurodevelopmental scores, highlighting the evolving nature of these outcomes based on cardiac diagnosis.

Background

Neurodevelopmental delays in children with congenital heart disease are significant, affecting up to half of those requiring surgical intervention. These delays can lead to long-term cognitive and social-emotional challenges, impacting educational and employment outcomes in adulthood. Understanding the multifactorial causes of these delays is crucial for improving care and outcomes in this vulnerable population.

Data Highlights

No numerical data available in the provided material.

Key Findings

  • Neurodevelopmental outcomes vary by cardiac diagnosis, with evolving associations noted in recent studies.
  • Clinical risk factors include genetic diagnoses, prolonged hospitalization, and preterm birth.
  • Social determinants such as parental education level and socioeconomic status are linked to neurodevelopmental outcomes.
  • Standardized neurodevelopmental measures were utilized across 27 CNOC sites for data collection.
  • Improved outcomes have been observed in patients with dextro-transposition of the great arteries compared to earlier findings.

Clinical Implications

Healthcare providers should consider both medical and social factors when assessing neurodevelopmental outcomes in children with CHD. Early identification and intervention strategies are essential to address potential delays and improve long-term outcomes.

Conclusion

The study underscores the importance of understanding the interplay between medical and social factors in neurodevelopmental outcomes for children with congenital heart disease. Ongoing research and data collection are vital for refining care strategies.

Related Resources & Content

  1. Pediatric Cardiology, 2020 -- Assessment of Early Development and the Influence of Socioeconomic Factors on Neurodevelopment in Infants Diagnosed with Tetralogy of Fallot
  2. Pediatric Cardiology, 2018 -- Analysis of Placental Features in Newborns with Congenital Heart Defects: Variations According to Cardiac Anomaly Type
  3. Pediatric Cardiology, 2025 -- Impact of Congenital Heart Defect Severity on Long-Term Physical Development
  4. Professional Heart Daily, 2024 -- Neurodevelopmental Outcomes for Individuals With Congenital Heart Disease: Updates in Neuroprotection, Risk-Stratification, Evaluation, and Management
  5. Pediatric Cardiology — Child Opportunity Index and Prevalence of Obesity and Hypertension in Adolescents with Congenital Heart Disease
  6. Neurodevelopmental assessment of children with congenital heart disease: a Meta analysis based on the Bayley Scales of Infant Development and Wechsler Intelligence Scale
  7. Neurodevelopmental Outcomes After Nitric Oxide During Cardiopulmonary Bypass for Open Heart Surgery: A Randomized Clinical Trial
  8. Neurodevelopmental Outcomes for Individuals With Congenital Heart Disease: Updates in Neuroprotection, Risk-Stratification, Evaluation, and Management - Professional Heart Daily | American Heart Association

Original Source(s)

Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease

  • by Mike Seed, Dawn Ilardi, Valerie Rofeberg, Cynthia Ortinau, Caren Goldberg, Garrett Reichle, Lauren Bush, Justin Elhoff, Amy Jo Lisanti, Jennifer Butcher, Caitlin Rollins, Andrew Van Bergen, Shabnam Peyvandi, Emily Bucholz, Stephanie Cox, Lyla Hampton, Jacqueline Sanz, Sonia Monteiro, Shruti Tewar, Kiona Allen, Caroline Lee, Kristi Glotzbach, Nneka Alexander, Laurel Bear, Corinne Anton, Renee Sananes, Linh Ly, Gina Boucher, Kelly Wolfe, Lindsay Edwards, Elizabeth Willen, Alexander Tan, Christina Ortega, Erica Sood, Anjali Sadhwani, Kari Crawford Plant, Lauren Quigley, Jessica Pliego, Elizabeth Valles, Abbey Hines, David Wypij, Thomas Miller

  • June 1, 2026

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