Clinical Report: Linking Obstructive Sleep Apnea Syndrome to Variability in Blood Pressure

Overview

This meta-analysis evaluates the association between obstructive sleep apnea syndrome (OSAS) and blood pressure variability (BPV) using ambulatory blood pressure monitoring. Findings indicate that OSAS is linked to significantly higher BPV, particularly during nighttime.

Background

Obstructive sleep apnea syndrome (OSAS) affects a significant portion of the adult population and is associated with various cardiovascular risks, including hypertension and heart disease. This study aims to evaluate the association between OSAS and blood pressure variability (BPV) compared to non-OSAS controls.

Data Highlights

Key Findings

• OSAS is associated with significantly higher BPV compared to non-OSAS controls.
• Nighttime BPV shows the largest differences in both systolic and diastolic blood pressure.
• Subgroup analyses indicate a trend toward increased BPV with greater OSAS severity.
• Mean age, proportion of men, and mean body mass index were not significant modifiers of BPV outcomes.
• The certainty of evidence regarding the association between OSAS and BPV ranged from low to very low.

Clinical Implications

Monitoring BPV may provide insights into the cardiovascular health of patients with OSAS.

Conclusion

OSAS is linked to increased BPV, particularly at night, although the evidence quality is low.

Related Resources & Content

1. Author(s)/Org, Source, Year -- Title
2. Frontiers in Neurology — Effects of mandibular advancement devices vs. CPAP on blood pressure in obstructive sleep apnea: a systematic review and meta-analysis of randomized controlled trials
3. Frontiers in Cardiovascular Medicine — Association between nocturnal and morning blood pressure in patients with obstructive sleep apnea analysis: according to sex
4. European Journal of Preventive Cardiology — From variability to vulnerability: the prognostic significance of blood pressure fluctuations
5. npj Digital Medicine — Multi night digital assessment of sleep disordered breathing is associated with accelerated vascular aging
6. Effects of mandibular advancement devices vs. CPAP on blood pressure in obstructive sleep apnea: a systematic review and meta-analysis of randomized controlled trials
7. Association between nocturnal and morning blood pressure in patients with obstructive sleep apnea analysis: according to sex
8. From variability to vulnerability: the prognostic significance of blood pressure fluctuations
9. https://academic.oup.com/ajh/article/39/2/185/8269324
10. Frontiers | Association between obstructive sleep apnea syndrome and blood pressure variability: a meta-analysis
11. Effects of CPAP on Blood Pressure Parameter Across Different Severities of Obstructive Sleep Apnoea: A Meta-Analysis - PubMed