Response quality of large language models on periprosthetic fractures: A comparative evaluation of ChatGPT, Gemini, and Claude - Report - MDSpire
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Evaluating the Quality of Responses from Large Language Models on Periprosthetic Fractures: A Comparison of ChatGPT, Gemini, and Claude

  • By

  • Buğra Can

  • Anıl Agar

  • İrfan Arslan

  • September 29, 2026

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Clinical Report: Evaluating the Quality of Responses from Large Language Models

Overview

This study compares the accuracy and quality of responses from three large language models (LLMs) regarding periprosthetic fractures.

Background

The increasing reliance on large language models (LLMs) for health information raises concerns about the accuracy and reliability of their outputs. Periprosthetic fractures are significant complications following arthroplasty, necessitating precise information for effective patient management.

Data Highlights

No numerical or trial data was provided in the source material.

Key Findings

  • LLMs can produce fluent text but may also convey inaccurate information, a phenomenon known as hallucination.
  • Periprosthetic femoral fractures are a major complication after total hip arthroplasty, linked to high morbidity and healthcare costs.
  • Standardized classification frameworks, such as the Vancouver classification, are essential for evaluating and treating periprosthetic fractures.
  • Comparative data on the accuracy and quality of LLM responses regarding periprosthetic fractures are limited.

Clinical Implications

Healthcare professionals should be cautious when utilizing LLMs for clinical inquiries, especially in high-risk areas such as periprosthetic fractures. The potential for inaccurate information necessitates careful evaluation of LLM outputs before patient consultation.

Conclusion

The study underscores the need for further research into the reliability of LLMs in providing accurate medical information, particularly for complex clinical scenarios like periprosthetic fractures.

Related Resources & Content

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  5. ASCO Publications — Evaluating reliability of large language models for patient queries: Concordance with NCCN invasive breast cancer guideline using ChatGPT, DeepSeek, and Gemini.
  6. Archives of Orthopaedic and Trauma Surgery — Artificial intelligence advancements for orthopaedic clinical reasoning: longitudinal assessment of newer models (ChatGPT-5, Grok-3, Gemini 2.5 Flash) compared to clinicians
  7. Management of Fragility Femoral Fractures: A UK Regional Multicentre Audit of the British Orthopaedic Association Standards for Trauma (BOAST) Guidelines - PMC
  8. Effectiveness of open reduction internal fixation versus revision arthroplasty around Vancouver type B2 periprosthetic femoral fractures: a systematic review and meta-analysis | BMC Musculoskeletal Disorders | Springer Nature Link
  9. Comparative Outcomes of Distal Femoral Replacement Versus Operative Fixation for Periprosthetic Distal Femur Fractures: A Systematic Review and Meta-Analysis - PMC

Original Source(s)

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