Association between glucolipid metabolic indicators and the risk of suspected precocious puberty in children living with obesity: a retrospective cohort study - Report - MDSpire
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Association between glucolipid metabolic indicators and the risk of suspected precocious puberty in children living with obesity: a retrospective cohort study
Linking glucolipid metabolic markers to precocious puberty in obese children
Overview
This study investigates the association between glucolipid metabolic indicators and suspected precocious puberty (PP) in obese children. Findings indicate that higher insulin resistance, triglycerides, and uric acid levels are linked to suspected PP, while higher HDL-C levels appear protective.
Background
Precocious puberty can lead to various health issues, including reduced adult height and psychological challenges. The rising incidence of precocious puberty, particularly in children with obesity, underscores the need for identifying metabolic risk factors. Understanding these associations can inform early intervention strategies to mitigate long-term health risks.
Data Highlights
Metabolic Indicator
Suspected PP Group
Non-PP Group
FPG
Higher
Lower
FINS
Higher
Lower
HOMA-IR
Higher
Lower
TG
Higher
Lower
HDL-C
Lower
Higher
Bone Age Advancement
1.88 ± 0.64 years
0.86 ± 0.48 years
Key Findings
Suspected PP group had significantly higher FPG, FINS, HOMA-IR, TG, TC, LDL-C, and uric acid levels.
Lower HDL-C levels were observed in the suspected PP group compared to non-PP.
Logistic regression identified HOMA-IR, TG, and uric acid as independent risk factors for suspected PP.
Higher HDL-C levels were found to be protective against suspected PP.
Bone age advancement was significantly greater in the suspected PP group.
Clinical Implications
Healthcare providers should consider metabolic monitoring in obese children, particularly those showing signs of precocious puberty. Early identification of insulin resistance and dyslipidemia may facilitate timely interventions to prevent adverse outcomes associated with early puberty.
Conclusion
The study highlights a significant association between glucolipid metabolic markers and suspected precocious puberty in obese children, emphasizing the need for early metabolic assessment in this population.
