A comparative study of conventional, High-flow, and jet ventilation via the Wei nasal jet tube for oxygen therapy in patients undergoing bronchoscopic intervention under deep sedation: a randomized controlled trial - Report - MDSpire

A comparative study of conventional, High-flow, and jet ventilation via the Wei nasal jet tube for oxygen therapy in patients undergoing bronchoscopic intervention under deep sedation: a randomized controlled trial

  • By

  • Ai-Di Zhang

  • Xiang Ge

  • Xiao-Li Li

  • Qing-Hao Cheng

  • Ming-Yuan Yang

  • June 24, 2026

  • 0 min

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Clinical Report: Comparing Oxygen Therapy Methods During Bronchoscopy

Overview

This study evaluated the efficacy of supraglottic jet oxygenation (SJOV) via the Wei nasal jet tube against conventional oxygen therapy (COT) and high-flow nasal cannula (HFNC) during bronchoscopic procedures under deep sedation. SJOV demonstrated a significant reduction in hypoxemia and improved oxygenation compared to COT.

Background

Hypoxemia is a common complication during bronchoscopic interventions, particularly in patients with mild-to-moderate airway stenosis. Conventional oxygen therapy often proves inadequate, leading to increased risks during procedures. The Wei nasal jet tube offers a novel approach to oxygenation and ventilation.

Data Highlights

OutcomeSJOVCOTHFNC
Incidence of Hypoxemia (SpO2 < 90%)LowerHigher-
Incidence of Severe Hypoxemia (SpO2 < 80%)LowerHigher-
MPPO RequirementLowerHigher-
PaO2 LevelsHigherLowerLower
Lactic Acid LevelsLowerHigherHigher

Key Findings

  • SJOV resulted in a significantly lower incidence of hypoxemia compared to COT (P = 0.018).
  • The incidence of severe hypoxemia was also significantly lower in the SJOV group compared to COT (P = 0.016).
  • Mask positive-pressure oxygenation (MPPO) requirements were significantly lower in the SJOV group (P = 0.014).
  • PaO2 levels were significantly higher in the SJOV group compared to both COT and HFNC (P < 0.001).
  • Lactic acid levels were significantly lower in the SJOV group compared to both COT (P < 0.001) and HFNC (P = 0.006).

Clinical Implications

The findings indicate that SJOV via the Wei nasal jet tube may reduce the incidence of hypoxemia during bronchoscopic procedures.

Conclusion

SJOV using the Wei nasal jet tube improved oxygenation and reduced hypoxemia compared to COT during bronchoscopic interventions.

Related Resources & Content

  1. Frontiers in Medicine, 2026 -- Respiratory safety and resource utilization in ERCP: a comparative study of high-flow nasal oxygen, conventional mask, and general anesthesia in high-risk populations
  2. Intensive Care Medicine, 2009 -- Feasibility Study of a Novel Face Mask for Non-Invasive Mechanical Ventilation During Diagnostic Bronchoscopy
  3. Intensive Care Medicine, 2010 -- Review of Key Developments in Intensive Care Medicine for 2009: Focus on Mechanical Ventilation, Acute Lung Injury, Respiratory Distress Syndrome, Pediatric Considerations, Ethical Issues, and Additional Topics
  4. Updates in Surgery, 2024 -- Evaluation of Postoperative Respiratory Complications and Intraoperative Safety in Non-Intubated versus Intubated Anesthesia for Thoracoscopic Surgery: A Randomized, Controlled, Double-Blind Non-Inferiority Study
  5. Guidance and monitoring -- 2025 S2k safety guideline for diagnostic flexible bronchoscopy in adults
  6. Frontiers in Medicine, 2025 -- High-flow nasal cannula oxygenation reduces desaturation risk during diagnostic flexible bronchoscopy under deep sedation: a randomized controlled trial
  7. BMC Anesthesiology -- Subglottic jet ventilation versus supraglottic jet ventilation for flexible bronchoscopy: a randomized controlled trial
  8. Deckblatt Leitlinien
  9. High-flow nasal cannula oxygenation reduces desaturation risk during diagnostic flexible bronchoscopy under deep sedation: a randomized controlled trial
  10. Subglottic jet ventilation versus supraglottic jet ventilation for flexible bronchoscopy: a randomized controlled trial | BMC Anesthesiology | Springer Nature Link

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