Artificial intelligence for predicting and preventing adverse pregnancy outcomes addressing bias and clinical translation - Report - MDSpire

Artificial intelligence for predicting and preventing adverse pregnancy outcomes addressing bias and clinical translation

  • By

  • Sharmake Gaiye Bashir

  • Hiba Abdi Salad

  • Yakub Burhan Abdullahi

  • Yusuf Hared Abdi

  • Mohamed Sharif Abdi

  • Naima Ibrahim Ahmed

  • Shuaibu Saidu Musa

  • Nafisa M. K. Elehamer

  • Muhammad Kabir Musa

  • Obasanjo Bolarinwa

  • Olusegun Dada

  • June 19, 2026

  • 0 min

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Clinical Report: Utilizing Artificial Intelligence to Forecast Pregnancy Outcomes

Overview

This review highlights the potential of artificial intelligence (AI) in predicting adverse pregnancy outcomes, emphasizing the variability in predictive performance and the presence of algorithmic biases. It identifies key challenges in the clinical application of AI, particularly regarding equity in maternal healthcare.

Background

Maternal and perinatal mortality remains a significant global health issue, especially in low- and middle-income countries. Traditional risk assessment methods for adverse pregnancy outcomes are limited in sensitivity and specificity, necessitating improved predictive tools. AI offers a promising alternative by enabling enhanced risk prediction and clinical decision support.

Data Highlights

The predictive performance of AI models for obstetric complications shows considerable variability, with AUROC values ranging from 0.73 to 0.97 across different studies.

Key Findings

  • AI applications have demonstrated predictive accuracies exceeding 85% for various obstetric complications.
  • Eight key bias mechanisms affecting AI model performance were identified, including sampling bias and algorithmic bias.
  • Current evidence is limited by a lack of external validation across diverse populations.
  • There is a need for rigorous multisite validation and inclusive dataset development to enhance model generalizability.
  • AI's integration into clinical workflows requires careful oversight to ensure equitable implementation.

Clinical Implications

Healthcare professionals should be aware of the limitations and biases associated with AI models in maternal health. Ensuring transparency and accountability in AI development is crucial for equitable healthcare delivery.

Conclusion

The integration of AI in maternal healthcare presents both opportunities and challenges, necessitating careful consideration of biases and validation processes to improve outcomes.

Related Resources & Content

  1. Frontiers in Reproductive Health, 2026 -- Regulating algorithmic tools in reproductive health: ethical and legal challenges
  2. conexiant -- Can AI Predict Preterm Birth in Diabetic, Hypertensive Pregnancies?
  3. cedars-sinai pulse -- Machine Learning Used to Predict Postpartum Depression Risk
  4. BMC Pregnancy and Childbirth -- Machine learning based classification in obstetrics: evaluating models, partitioning strategies, and key predictors in cardiotocography
  5. Updated Clinical Guidance for the Use of Progestogen Supplementation for the Prevention of Recurrent Preterm Birth | ACOG
  6. Society for Maternal-Fetal Medicine Special Statement: Updated checklists for preeclampsia risk-factor screening
  7. Management of Diabetes in Pregnancy: Standards of Care in Diabetes—2026 | American Diabetes Association
  8. Machine learning models for predicting preeclampsia: a systematic review | BMC Pregnancy and Childbirth | Springer Nature Link
  9. The early prediction of gestational diabetes mellitus by machine learning models | BMC Pregnancy and Childbirth | Springer Nature Link
  10. Prediction of adverse maternal and perinatal outcomes associated with pre-eclampsia and hypertensive disorders of pregnancy: a systematic review and meta-analysis
  11. Kim et al. BMC Pregnancy and Childbirth (2025) 25:916
  12. Randomised study of human machine collaboration for cardiotocography interpretation during labour
  13. TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods - PMC
  14. Final FDA guidance on PCCP includes clarification on version control | RAPS
  15. Ethics and governance of artificial intelligence for health: large multi-modal models. WHO guidance

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