Sphincter-saving surgery versus abdominoperineal resection in low rectal cancer: the role of indocyanine green fluorescence angiography in surgical decision-making - Report - MDSpire

Sphincter-saving surgery versus abdominoperineal resection in low rectal cancer: the role of indocyanine green fluorescence angiography in surgical decision-making

  • By

  • Mihaela C. Misca

  • Sorin V. Petrea

  • Roxana D. Boanta

  • Sorin Aldoescu

  • Eduard Catrina

  • Mihaela E. Vilcu

  • V. Grigorean

  • V. Strambu

  • Iulian Brezean

  • July 9, 2026

  • 0 min

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Clinical Report: Comparing Sphincter-Sparing Surgery and Abdominoperineal Resection

Overview

This study evaluates the impact of indocyanine green fluorescence angiography (ICG-FA) on surgical decisions for low rectal cancer. ICG-FA modified the resection line in 40% of cases.

Background

Low rectal cancer poses significant challenges in surgical management, particularly in balancing oncological outcomes with functional preservation. The introduction of ICG-FA aims to enhance intraoperative decision-making by assessing bowel perfusion, a critical factor in preventing anastomotic failure.

Data Highlights

ParameterValue
Patients with low rectal cancer70
Patients undergoing sphincter-saving surgery27
ICG-FA performed22 (81.5%)
Modification of resection line due to ICG-FA9 (40%)
R0 resection achieved19 of 21
Postoperative complications15 of 27 (56%)

Key Findings

  • ICG-FA was performed in 81.5% of patients undergoing sphincter-saving surgery.
  • Modification of the resection line occurred in 40% of cases where ICG-FA was utilized.
  • R0 resection was achieved in 90.5% of patients with recorded margin status.
  • Postoperative complications were observed in 56% of patients, primarily classified as Clavien–Dindo grade I–II.
  • No 30-day mortality was reported; one late in-hospital death occurred due to myocardial infarction.

Clinical Implications

The use of ICG-FA may assist surgeons in making informed intraoperative decisions regarding resection lines. However, the high rate of postoperative complications highlights the need for careful patient management.

Conclusion

Sphincter-saving surgery for low rectal cancer is feasible but associated with significant morbidity.

Related Resources & Content

  1. Frontiers in Surgery, 2026 -- Indocyanine green fluorescence angiography in laparoscopic sigmoid and rectal cancer surgery: no reduction in anastomotic leakage but a lower incidence of anastomotic strictures.
  2. Frontiers in Surgery, 2026 -- Beyond fluorescence intensity: a Minimum acquisition and reporting standard and emerging technologies for colorectal indocyanine green fluorescence angiography studies.
  3. Techniques in Coloproctology, 2025 -- The Role of Fluorescence Laparoscopic Surgery in Preventing Anastomotic Leakage in Ultra-Low Rectal Cancer: A Multicenter Retrospective Analysis with Neoadjuvant Chemoradiotherapy Considerations.
  4. Frontiers in Medicine, 2026 -- The effectiveness of intraoperative indocyanine green fluorescence imaging in preventing anastomotic leakage after minimally invasive esophagectomy for esophageal cancer: a systematic review and meta-analysis.
  5. Localised rectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up - PubMed.
  6. Intraoperative fluorescence angiography with indocyanine green to prevent anastomotic leak in rectal cancer surgery (IntAct): an unblinded randomised controlled trial - ScienceDirect.
  7. Localised rectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up - PubMed
  8. Intraoperative fluorescence angiography with indocyanine green to prevent anastomotic leak in rectal cancer surgery (IntAct): an unblinded randomised controlled trial - ScienceDirect
  9. Impact of indocyanine green fluorescence angiography on the prevention of anastomotic leakage in mid- and low-rectal cancer surgery: A systematic review and meta-analysis - PMC

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