Clinical Report: The role of the systemic inflammation response index (SIRI) as a mediator

Overview

This study investigates the role of the systemic inflammation response index (SIRI) as a mediator between the apolipoprotein B/A1 ratio and atrial fibrillation (AF).

Background

Atrial fibrillation (AF) is a prevalent arrhythmia linked to significant morbidity and mortality. The apolipoprotein B/A1 ratio serves as a marker for lipid metabolism and cardiovascular risk, while systemic inflammation has been implicated in AF pathogenesis.

Data Highlights

Key Findings

• SIRI acts as a partial mediator in the relationship between ApoB/ApoA1 and AF.
• The combined model of ApoB/ApoA1 and SIRI shows a significantly higher AUC compared to ApoB/ApoA1 alone (P < 0.001).
• The integrated model also demonstrates a larger AUC than SIRI alone (P = 0.002).
• The combined model achieved improved specificity and the lowest Brier score.
• Findings are consistent regardless of lipid-lowering drug use.

Clinical Implications

The findings suggest that incorporating SIRI with the ApoB/ApoA1 ratio may enhance the identification of patients at risk for atrial fibrillation. This combined approach could serve as a valuable tool for patient stratification in clinical settings.

Conclusion

The study highlights the role of SIRI in mediating the relationship between lipid profiles and atrial fibrillation.

Related Resources & Content

1. Clinical Research in Cardiology, Springer, 2026 -- The prognostic value of systemic inflammatory response index (SIRI) in acute coronary syndrome patients treated with primary percutaneous coronary intervention: a meta-analysis and systematic review
2. Frontiers in Cardiovascular Medicine, 2026 -- Systemic immune-inflammation Index and blood pressure control are independent and interactive predictors of atrial fibrillation recurrence after ablation
3. Frontiers in Medicine, 2026 -- Systemic inflammatory response index is associated with increased all-cause and cardiovascular mortality in obstructive sleep apnea: evidence from NHANES and validation with an external hospital-based dataset
4. 2024 Atrial Fibrillation Guidelines
5. Frontiers in Cardiovascular Medicine — Association of systemic inflammation response index and triglyceride-glucose index with the severity of coronary artery stenosis in elderly patients: a retrospective cross-sectional study
6. 2024 Atrial Fibrillation
7. A novel systemic inflammation response index (SIRI) for predicting the survival of patients with pancreatic cancer after chemotherapy - Qi - 2016 - Cancer - Wiley Online Library
8. Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation | Nature Communications