Incorporating Race in Clinical Algorithms—A Response
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By
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James A. Diao
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Emma Pierson
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October 1, 2026
Clinical Report: Incorporating Race in Clinical Algorithms—A Response
Background
The incorporation of race in clinical algorithms raises concerns about accuracy, equity, and health disparities. Evaluating both race-aware and race-neutral approaches in algorithm design is important.
Data Highlights
No numerical data provided in the source material.
Key Findings
- Patient preferences are a critical factor in the design of clinical algorithms.
- Incorporating race into algorithms presents methodological challenges, including misidentification by clinicians.
- Race-neutral approaches should be favored when their performance is comparable to race-aware algorithms.
- Comparative assessments of race-aware versus race-neutral algorithms are necessary before removing race from clinical considerations.
- Race often serves as a proxy for unmeasured factors that algorithms currently cannot incorporate.
- Systemic measures are required to address structural disparities beyond algorithmic modifications.
Clinical Implications
Clinicians should consider patient preferences in their decision-making processes. A careful evaluation of the impact of race-aware versus race-neutral algorithms is essential.
Conclusion
The discussion around race in clinical algorithms necessitates a balanced approach that considers methodological rigor and implications for health equity.
Related Resources & Content
- Diao et al., JAMA Internal Medicine, 2022 -- Incorporating Racial Identity in Clinical Decision-Making Algorithms
- Pfob and Sidey-Gibbons, ASCO Publications, 2021 -- Systematic Bias in Medical Algorithms: To Include or Not Include Discriminatory Demographic Information?
- The Pathologist, 2024 -- Time to Rethink Race-based Research?
- American College of Cardiology/American Heart Association, 2026 -- 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia
- KDIGO, 2024 -- KDIGO 2024 CKD Guideline
- American Thoracic Society, 2021 -- ATS Publishes Official Statement on Race, Ethnicity, and Pulmonary Function Test Interpretation
- ASCO Publications — Has racial and ethnic representation in oncology clinical trials changed?: A 30-year systematic analysis using artificial intelligence.
- 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | Circulation
- https://kdigo.org/wp-content/uploads/2026/04/KDIGO-2024-CKD-Guideline.pdf
- American Thoracic Society | ATS Publishes Official Statement on Race,…
Based on findings from:
Use of Race in Clinical Algorithms—Reply
James A. Diao, Emma Pierson. Jama Internal Medicine, 2026.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2852478
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.