Use of Race in Clinical Algorithms—Reply - Report - MDSpire
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Incorporating Race in Clinical Algorithms—A Response

  • By

  • James A. Diao

  • Emma Pierson

  • October 1, 2026

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Clinical Report: Incorporating Race in Clinical Algorithms—A Response

Background

The incorporation of race in clinical algorithms raises concerns about accuracy, equity, and health disparities. Evaluating both race-aware and race-neutral approaches in algorithm design is important.

Data Highlights

No numerical data provided in the source material.

Key Findings

  • Patient preferences are a critical factor in the design of clinical algorithms.
  • Incorporating race into algorithms presents methodological challenges, including misidentification by clinicians.
  • Race-neutral approaches should be favored when their performance is comparable to race-aware algorithms.
  • Comparative assessments of race-aware versus race-neutral algorithms are necessary before removing race from clinical considerations.
  • Race often serves as a proxy for unmeasured factors that algorithms currently cannot incorporate.
  • Systemic measures are required to address structural disparities beyond algorithmic modifications.

Clinical Implications

Clinicians should consider patient preferences in their decision-making processes. A careful evaluation of the impact of race-aware versus race-neutral algorithms is essential.

Conclusion

The discussion around race in clinical algorithms necessitates a balanced approach that considers methodological rigor and implications for health equity.

Related Resources & Content

  1. Diao et al., JAMA Internal Medicine, 2022 -- Incorporating Racial Identity in Clinical Decision-Making Algorithms
  2. Pfob and Sidey-Gibbons, ASCO Publications, 2021 -- Systematic Bias in Medical Algorithms: To Include or Not Include Discriminatory Demographic Information?
  3. The Pathologist, 2024 -- Time to Rethink Race-based Research?
  4. American College of Cardiology/American Heart Association, 2026 -- 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia
  5. KDIGO, 2024 -- KDIGO 2024 CKD Guideline
  6. American Thoracic Society, 2021 -- ATS Publishes Official Statement on Race, Ethnicity, and Pulmonary Function Test Interpretation
  7. ASCO Publications — Has racial and ethnic representation in oncology clinical trials changed?: A 30-year systematic analysis using artificial intelligence.
  8. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | Circulation
  9. https://kdigo.org/wp-content/uploads/2026/04/KDIGO-2024-CKD-Guideline.pdf
  10. American Thoracic Society | ATS Publishes Official Statement on Race,…

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