Clinical characteristics of Chlamydia pneumoniae pneumonia in 145 children: a single-centre retrospective study - Report - MDSpire

Clinical characteristics of Chlamydia pneumoniae pneumonia in 145 children: a single-centre retrospective study

  • By

  • Yongkang Wang

  • Tianyu Huang

  • Weikang Gao

  • Yun Liu

  • Wenna Shen

  • Tingting Yang

  • Hongchuan Yu

  • Xinrong Sun

  • June 25, 2026

  • 0 min

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Clinical Features of Chlamydia pneumoniae Pneumonia in 145 Pediatric Patients

Overview

This study analyzes the clinical features of Chlamydia pneumoniae pneumonia in 145 children, highlighting cough as the predominant symptom and low to moderate fever as a common finding.

Background

Chlamydia pneumoniae is an atypical pathogen that can lead to respiratory diseases in children, including pneumonia. Its clinical manifestations often overlap with other respiratory infections, making diagnosis challenging.

Data Highlights

CharacteristicValue
Median Age at Onset11 years
Median Disease Duration14 days
Cough Presence99.3%
Fever Presence44.8%
Unilateral Lung Involvement109 cases
Bilateral Lung Involvement36 cases

Key Findings

  • Cough was present in 99.3% of cases, with wet cough in 97.2%.
  • Fever was observed in 44.8% of patients, primarily low to moderate grade.
  • The median peak temperature recorded was 38.5°C.
  • Unilateral lung involvement was noted in 109 cases, while bilateral involvement was seen in 36 cases.
  • 93 children received azithromycin, and 65 received doxycycline for treatment.

Clinical Implications

Recognizing the characteristic clinical features of Chlamydia pneumoniae pneumonia, such as predominant cough and low-grade fever, should be prioritized for diagnosis.

Conclusion

The study provides insights into the clinical features of Chlamydia pneumoniae pneumonia in children.

Related Resources & Content

  1. CDC, Clinical Overview of Chlamydia pneumoniae Infection, 2025 -- Clinical Overview of Chlamydia pneumoniae Infection
  2. Frontiers in Pediatrics, Risk factors for severe Chlamydia pneumoniae pneumonia in children: a retrospective case–control study, 2026 -- Risk factors for severe Chlamydia pneumoniae pneumonia in children: a retrospective case–control study
  3. European Journal of Clinical Microbiology & Infectious Diseases, Sharp increase in Chlamydia pneumoniae infections in 2024 in Germany, 2025 -- Sharp increase in Chlamydia pneumoniae infections in 2024 in Germany
  4. Frontiers in Pediatrics — Clinical characteristics, predictive factors, and therapeutic outcomes of mycoplasma pneumoniae pneumonia with pleural effusion in children: a retrospective cohort study
  5. Frontiers in Pediatrics — Clinical characteristics and risk factors of necrotizing pneumonia secondary to severe pneumonia in children
  6. Infection — Co-infection of SARS-CoV-2 with Chlamydia and Mycoplasma pneumoniae: A Case Series and Literature Review
  7. Clinical Overview of Chlamydia pneumoniae Infection | C. pneumoniae | CDC
  8. Sharp increase in Chlamydia pneumoniae infections in 2024 in Germany | European Journal of Clinical Microbiology & Infectious Diseases | Springer Nature Link
  9. Risk factors for severe Chlamydia pneumoniae pneumonia in children: a retrospective case–control study

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