The association between C-reactive protein-triglyceride glucose index and all-cause mortality in patients with cardiovascular-kidney-metabolic syndrome: a single-center retrospective cohort study - Report - MDSpire

The association between C-reactive protein-triglyceride glucose index and all-cause mortality in patients with cardiovascular-kidney-metabolic syndrome: a single-center retrospective cohort study

  • By

  • Jiacai Lin

  • Shaobin Qiu

  • Shuling Su

  • Weixin Ni

  • Yongluan Lin

  • Xiaobin Ni

  • July 8, 2026

  • 0 min

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Clinical Report: C-Reactive Protein-Triglyceride Glucose Index and Mortality in CKM

Overview

This study investigates the prognostic value of the C-reactive protein-triglyceride glucose index (CTI) in predicting all-cause mortality among patients with cardiovascular-kidney-metabolic (CKM) syndrome. Findings indicate that CTI is an independent predictor of mortality across different stages of CKM.

Background

Cardiovascular-kidney-metabolic syndrome (CKM) is associated with high mortality risk, necessitating effective risk stratification tools. The CTI integrates markers of inflammation and insulin resistance.

Data Highlights

StageHazard Ratio (HR)95% Confidence Interval (CI)
Stage 0–31.681.30–2.18
Stage 41.541.33–1.77
Q4 vs Q1 (Stage 0–3)4.572.32–8.99
Q4 vs Q1 (Stage 4)2.261.64–3.13

Key Findings

  • CTI is an independent predictor of all-cause mortality in CKM patients.
  • CTI shows a linear dose-response relationship with mortality risk.
  • Patients in the highest CTI quartile (Q4) have significantly higher mortality risk compared to those in the lowest quartile (Q1).
  • CTI outperforms the TyG index in predicting 1-year mortality.
  • The study included a large cohort of 8,632 CKM patients.

Clinical Implications

The CTI may serve as a tool for identifying high-risk CKM patients.

Conclusion

CTI is a significant predictor of mortality in CKM.

Related Resources & Content

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  6. Frontiers in Medicine — Association between the C-reactive protein-triglyceride-glucose index and major adverse cardiovascular events in patients undergoing percutaneous coronary intervention
  7. 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome - Professional Heart Daily | American Heart Association
  8. The American Diabetes Association Releases “Standards of Care in Diabetes—2026” | American Diabetes Association
  9. Triglyceride-Glucose Index and Mortality Risk in the General Population: A Systematic Review and Meta-analysis of Prospective Studies | High Blood Pressure & Cardiovascular Prevention | Springer Nature Link

Original Source(s)

The association between C-reactive protein-triglyceride glucose index and all-cause mortality in patients with cardiovascular-kidney-metabolic syndrome: a single-center retrospective cohort study

  • by Jiacai Lin, Shaobin Qiu, Shuling Su, Weixin Ni, Yongluan Lin, Xiaobin Ni

  • July 8, 2026

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