Clinicopathological, proliferative, molecular, and prognostic characteristics of differentiated high-grade thyroid carcinoma: a multicenter retrospective study - Report - MDSpire
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Clinicopathological, proliferative, molecular, and prognostic characteristics of differentiated high-grade thyroid carcinoma: a multicenter retrospective study
Clinical, Pathological, Proliferative, Molecular, and Prognostic Features of Differentiated High-Grade Thyroid Carcinoma
Overview
This study analyzes the clinicopathological characteristics of differentiated high-grade thyroid carcinoma (DHGTC), a newly defined subtype in the WHO Classification.
Background
Differentiated thyroid carcinoma (DTC) is the most common type of thyroid cancer, typically exhibiting indolent behavior. However, certain subtypes, such as DHGTC, demonstrate aggressive characteristics and poorer outcomes.
Data Highlights
Characteristic
Findings
Patient Gender
9 Male, 10 Female
Median Age
61 years (24–78 years)
Invasiveness
11 cases with adjacent structure involvement
Lymph Node Metastasis
13 cases
Ki-67 Index
All cases ≥10%, 10 cases ≥20%
BRAF Abnormalities
9 cases
Key Findings
DHGTC is characterized by high-grade pathological features including increased mitotic activity and tumor necrosis.
All cases exhibited a Ki-67 proliferation index of ≥10%, with some reaching 30%.
BRAF abnormalities were identified in 9 out of 19 cases.
During follow-up, 4 patients experienced recurrence or metastasis, and 2 patients died.
DHGTC retains the histological architecture of DTC while exhibiting aggressive behavior.
Clinical Implications
The identification of DHGTC as a distinct pathological entity necessitates careful evaluation of its aggressive features for accurate diagnosis and prognosis.
Conclusion
DHGTC represents a newly defined pathological entity in the classification of thyroid malignancies.
