Clinical Report: Adolescent Patient with Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma

Background

Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma (IEFVPTC) is a well-differentiated malignant thyroid tumor that is increasingly recognized as an independent entity in the 2022 WHO classification. It is more prevalent in adults and rare in children.

Data Highlights

Key Findings

• IEFVPTC is recognized as an independent entity in the 2022 WHO classification of endocrine tumors.
• The patient presented with a neck mass and ultrasound findings consistent with TI-RADS 4a.
• Preoperative management included oral methimazole to control thyroid function.
• Surgery involved total endoscopic transaxillary left thyroid lobectomy with confirmed minimally invasive IEFVPTC.
• No significant vascular invasion was noted in the pathological findings.
• Postoperative follow-up showed normal thyroid function with no complications.

Clinical Implications

Clinicians should maintain a high index of suspicion for IEFVPTC in adolescents presenting with hypervascular thyroid nodules. Early diagnosis and appropriate surgical intervention are crucial for favorable outcomes.

Conclusion

This case highlights the recognition of IEFVPTC in pediatric patients.

Related Resources & Content

1. Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach - PMC
2. 2022 European Thyroid Association Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma - PMC
3. Investigating Active Surveillance Strategies for Papillary Microcarcinoma of the Thyroid in Clinical Trials
4. Frontiers in Oncology — Synchronous metastatic differentiated high-grade thyroid carcinoma in lymph node from classic papillary thyroid carcinoma: a case report and literature review
5. Frontiers in Medicine — Multidisciplinary treatment of follicular thyroid carcinoma with hepatic and pulmonary metastases: a case report and literature review
6. Association of Multifocal Papillary Thyroid Cancer and Hashimoto's Thyroiditis with Increased Risk of Lymph Node Metastasis
7. Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach - PMC
8. 2022 European Thyroid Association Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma - PMC
9. Molecular Landscape and Therapeutic Strategies in Pediatric Differentiated Thyroid Carcinoma - PMC