Exploring the mechanism of acupuncture improving cognitive functions for post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome: study protocol of a randomized controlled trial with multimodal MRI - Report - MDSpire
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Exploring the mechanism of acupuncture improving cognitive functions for post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome: study protocol of a randomized controlled trial with multimodal MRI
Clinical Report: Investigating Acupuncture for Cognitive Abilities in PCME/CFS
Overview
This report outlines a randomized controlled trial designed to evaluate the efficacy of acupuncture in enhancing cognitive function in patients with post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome (PCME/CFS). The study will also explore the underlying neural mechanisms through multimodal MRI techniques.
Background
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a significant health concern, particularly as a sequelae of COVID-19, with cognitive dysfunction being a prevalent and debilitating symptom. Current treatment options are limited, making the exploration of complementary therapies like acupuncture critical. Understanding the mechanisms by which acupuncture may improve cognitive function could lead to more effective management strategies for affected patients.
Data Highlights
Measure
Details
Participants
129 patients with PCME/CFS and 30 healthy controls
Groups
Verum acupuncture, sham acupuncture, waitlist control
Treatment Duration
Three sessions per week for eight weeks
Primary Measure
Change in SDMT score from baseline to week 8
Secondary Measures
Multiple cognitive tests and assessments including DST, TMT, RAVLT, and more
Key Findings
The trial will assess the efficacy of acupuncture on cognitive function in PCME/CFS patients.
Multimodal MRI techniques will be utilized to investigate the neural mechanisms of acupuncture.
Participants will be randomly assigned to one of three groups: verum acupuncture, sham acupuncture, or waitlist control.
Primary outcome will be measured using the Symbol Digit Modality Test (SDMT).
Secondary outcomes will include various cognitive assessments and measures of fatigue and sleep quality.
Clinical Implications
The findings from this trial could provide insights into the potential role of acupuncture as a therapeutic intervention for cognitive dysfunction in PCME/CFS. If effective, acupuncture may offer a new avenue for treatment in a patient population with limited options.
Conclusion
This study aims to clarify the efficacy and mechanisms of acupuncture in improving cognitive function in patients with PCME/CFS, potentially contributing to better management strategies for this condition.
