Association between urinary hCG trajectories and the risk of miscarriage in women undergoing embryo transfer: a prospective cohort study - Report - MDSpire

Association between urinary hCG trajectories and the risk of miscarriage in women undergoing embryo transfer: a prospective cohort study

  • By

  • Jing Wang

  • Xin Wang

  • Liming Wang

  • Xiao Zhang

  • Pengfei Zang

  • Wenlong Han

  • Lu Chen

  • Qingkai Wang

  • Yi Li

  • Liyi Cai

  • June 4, 2026

  • 0 min

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Clinical Report: Relationship between urinary hCG patterns and miscarriage risk

Overview

This study investigates the association between urinary hCG trajectories and early miscarriage risk in women undergoing embryo transfer. Three distinct hCG patterns were identified, with specific trajectories linked to significantly increased miscarriage risks.

Background

Update statistics and references to reflect the most current data on miscarriage and IVF.

Data Highlights

hCG TrajectoryPercentageAdjusted Odds Ratio (aOR)95% Confidence Interval (CI)
Low-Slow15.5%38.1126.51-54.78
Low-Steady51.2%1.601.14-2.25
High-Steady33.3%--

Key Findings

  • Three distinct urinary hCG trajectories were identified: Low-Slow, Low-Steady, and High-Steady.
  • Low-Slow trajectory is associated with a significantly higher risk of miscarriage (aOR = 38.11).
  • Low-Steady trajectory also presents an increased risk of miscarriage (aOR = 1.60).
  • The predictive model demonstrated an AUC of 0.857 for miscarriage risk.
  • Early recognition of abnormal hCG dynamics can facilitate personalized clinical management.

Clinical Implications

Clinicians should consider urinary hCG trajectory patterns as potential indicators of miscarriage risk in patients undergoing embryo transfer. Early identification of Low-Slow and Low-Steady trajectories may allow for timely intervention and improved patient counseling.

Conclusion

Highlight the importance of further research to validate findings and their application in clinical settings.

Related Resources & Content

  1. Frontiers | Association between urinary hCG trajectories and the risk of miscarriage in women undergoing embryo transfer: a prospective cohort study
  2. Recurrent pregnancy loss: a committee opinion (2026) | American Society for Reproductive Medicine | ASRM
  3. Human chorionic gonadotropin value in early pregnancy after in vitro fertilization as a predictor of pregnancy outcome: a systematic review and meta-analysis - ScienceDirect
  4. The Journal of Clinical Endocrinology & Metabolism — Effects of Negative Pregnancy Experiences in the First IVF Cycle on Future Pregnancy Results
  5. Frontiers in Endocrinology — Outcomes of frozen embryo transfers from a large monocentric cohort (2982 cycles): towards a preferential use of cycles with a corpus luteum for endometrial preparation
  6. The Journal of Clinical Endocrinology & Metabolism — Elevated AMH Levels Correlate With Gestational Hypertension in PCOS Patients Undergoing IVF/ICSI with Fresh Embryo Transfer
  7. Frontiers in Endocrinology — Factors associated with de novo aneuploidy across different preimplantation genetic testing cycles: a retrospective cohort study
  8. Recurrent pregnancy loss: a committee opinion (2026) | American Society for Reproductive Medicine | ASRM
  9. Human chorionic gonadotropin value in early pregnancy after in vitro fertilization as a predictor of pregnancy outcome: a systematic review and meta-analysis - ScienceDirect
  10. Frontiers | Association between urinary hCG trajectories and the risk of miscarriage in women undergoing embryo transfer: a prospective cohort study

Original Source(s)

Association between urinary hCG trajectories and the risk of miscarriage in women undergoing embryo transfer: a prospective cohort study

  • by Jing Wang, Xin Wang, Liming Wang, Xiao Zhang, Pengfei Zang, Wenlong Han, Lu Chen, Qingkai Wang, Yi Li, Liyi Cai

  • June 4, 2026

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