Case Report: A rare triad of neoplasms: navigating synchronous accessory breast cancer, papillary thyroid carcinoma, and inflammatory nasal papilloma - Report - MDSpire

Case Report: A rare triad of neoplasms: navigating synchronous accessory breast cancer, papillary thyroid carcinoma, and inflammatory nasal papilloma

  • By

  • Xiangning Zeng

  • Huang Huang

  • Yuzhong Hong

  • Qin Meng

  • Kaihua Ye

  • Lian Zhou

  • Huajun Li

  • Ying Chen

  • Jiawei Huang

  • Chuxia Feng

  • June 1, 2026

  • 0 min

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Clinical Report: Managing a Unique Combination of Synchronous Neoplasms

Overview

This case study presents a 60-year-old woman diagnosed with accessory breast cancer, papillary thyroid carcinoma, and inflammatory nasal papilloma. It highlights the complexities of managing multiple synchronous neoplasms and emphasizes the importance of considering accessory breast carcinoma in differential diagnoses of axillary masses.

Background

The diagnosis of an isolated axillary mass in women with normal breast imaging poses significant clinical challenges. Accessory breast carcinoma is a rare entity that can be easily overlooked, leading to potential mismanagement. Understanding the management of synchronous primary tumors is crucial for optimizing patient outcomes.

Data Highlights

No numerical or trial data provided in the article.

Key Findings

  • The patient presented with a 1-year history of a painless, enlarging left axillary mass.
  • Imaging revealed a BI-RADS 5 lesion with suspicious lymph nodes but no primary breast abnormality.
  • Core needle biopsy confirmed grade II invasive ductal carcinoma of mammary origin.
  • Final pathology confirmed accessory breast carcinoma, papillary thyroid carcinoma, and nasal papilloma.
  • The management included neoadjuvant chemotherapy followed by sequential surgeries and adjuvant treatments.

Clinical Implications

This case underscores the necessity of including accessory breast carcinoma in the differential diagnosis of axillary masses. A multidisciplinary approach is essential for the effective management of patients with multiple synchronous tumors, ensuring that treatment is prioritized and sequenced appropriately.

Conclusion

The integration of a multidisciplinary strategy in managing synchronous neoplasms can significantly enhance patient care. This case illustrates the importance of thorough diagnostic evaluation and tailored treatment plans.

Related Resources & Content

  1. Conexiant, When Thyroid and Parathyroid Collide, 2023 -- A case of intrathyroidal parathyroid adenoma and papillary thyroid carcinoma
  2. The Pathologist, When Thyroid and Parathyroid Collide, 2023 -- A case of intrathyroidal parathyroid adenoma and papillary thyroid carcinoma
  3. Frontiers in Oncology, Synchronous lung adenocarcinoma in situ and type B2-B3 thymoma, 2023 -- A case report and multidisciplinary approach
  4. ASCO, Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: ASCO Guideline Clinical Insights, 2024 -- Clinical insights on axillary staging
  5. 2025 American Thyroid Association Management Guidelines, 2025 -- Guidelines for differentiated thyroid cancer management
  6. Frontiers in Oncology — Sequential multimodal management for recurrent pulmonary NUT carcinoma: a case report
  7. Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: ASCO Guideline Clinical Insights | JCO Oncology Practice
  8. 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer - Matthew D. Ringel, Julie Ann Sosa, Zubair Baloch, Lindsay Bischoff, Gary Bloom, Gregory A. Brent, Pamela L. Brock, Roger Chou, Robert R. Flavell, Whitney Goldner, Elizabeth G. Grubbs, Megan Haymart, Steven M. Larson, Angela M. Leung, Joseph Osborne, John A. Ridge, Bruce Robinson, David L. Steward, Ralph P. Tufano, Lori J. Wirth, 2025
  9. International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors - UCL Discovery
  10. Reciprocal cancer risks between thyroid and breast cancer: a systematic review and meta-analysis - ScienceDirect

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