Survival benefit of extended lymphadenectomy in endometrial cancer: a meta-analysis with risk-stratified subgroup analysis - Report - MDSpire

Survival benefit of extended lymphadenectomy in endometrial cancer: a meta-analysis with risk-stratified subgroup analysis

  • By

  • Yunlong Fan

  • Jun Zhu

  • Lingling Jiang

  • Jia Xu

  • Jinqun Huang

  • June 10, 2026

  • 0 min

Share

Clinical Report: Impact of Comprehensive Lymphadenectomy on Survival Outcomes

Overview

Revise to include source attribution for the statement on survival benefit variation.

Background

Remove unsupported claims regarding the necessity of understanding lymphadenectomy's impact.

Data Highlights

ComparisonHazard Ratio (HR)95% Confidence Interval (CI)
PPaLND vs No Lymphadenectomy0.610.49–0.75
PPaLND vs PLND0.600.44–0.81
Intermediate-to-High Risk Subgroup0.620.31–1.24
Intermediate Risk Group0.650.01–44.47
High Risk Group0.430.05–4.04

Key Findings

Remove conclusions about survival benefits that are not directly supported by the source.

Clinical Implications

The findings suggest that while PPaLND may improve overall survival for endometrial cancer patients, its benefits are not uniformly applicable across all risk groups. Clinicians should weigh the potential survival benefits against the risks of surgical complications when making treatment decisions.

Conclusion

Revise to reflect only findings without unsupported claims about further trials.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Author(s)/Org, Source, Year -- Title
  3. Author(s)/Org, Source, Year -- Title
  4. Author(s)/Org, Source, Year -- Title
  5. Guidelines, ESGO-ESTRO-ESP, 2025 -- Guidelines for Endometrial Cancer
  6. Author(s)/Org, Source, Year -- Title
  7. Analysis of the Incidence of Metastatic Lateral Lymph Nodes in Asian Individuals Undergoing Lateral Lymph Node Dissection for Rectal Cancer: A Meta-Analysis
  8. https://guidelines.esgo.org/media/2025/09/ESGO-ESTRO-ESP-Guidelines-for-EC_-LO-July-2025.pdf
  9. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study - PMC
  10. Therapeutic role of para-aortic lymphadenectomy in patients with intermediate- and high-risk endometrial cancer: a systematic review and meta-analysis - ScienceDirect

Original Source(s)

Related Content