Exercise testing in athletes: an adjunct to diagnose arrhythmogenic cardiomyopathy? - Report - MDSpire

Evaluating Exercise Testing in Athletes as a Tool for Diagnosing Arrhythmogenic Cardiomyopathy

  • By

  • Simon Wernhart

  • Martin Halle

  • Mark J. Haykowsky

  • Satyam Sarma

  • July 20, 2026

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Clinical Report: Evaluating Exercise Testing in Athletes for ACM Diagnosis

Background

Arrhythmogenic cardiomyopathy (ACM) is a hereditary condition that poses significant risks, including sudden cardiac death, particularly in athletes. The overlap between physiological adaptations in athletes and pathological changes in ACM complicates diagnosis, necessitating refined diagnostic criteria and risk assessment strategies. Current diagnostic frameworks may not adequately address the unique challenges presented by highly trained athletes.

Data Highlights

No numerical data or trial data provided in the source material.

Key Findings

  • ACM diagnosis in athletes is complicated by the overlap with physiological adaptations of the athletic heart.
  • Nearly one-third of elite athletes exhibit right ventricular dilatation, complicating diagnostic clarity.
  • Exercise testing may reveal regional wall motion abnormalities or inadequate ejection fraction increases, indicating potential underlying pathology.
  • A Qc/VO2 slope <5 during exercise may suggest central limitations indicative of subclinical ACM.
  • Future studies should focus on combined CPET and stress echocardiography to improve diagnostic accuracy in suspected ACM cases.

Clinical Implications

Clinicians should consider integrating exercise testing into the diagnostic evaluation of athletes suspected of ACM.

Conclusion

The integration of advanced exercise testing modalities may provide critical insights into the diagnosis and management of ACM in athletes, addressing current diagnostic challenges and improving patient outcomes.

Related Resources & Content

  1. European Journal of Preventive Cardiology, 2023 -- The timing and relationship of ventricular arrhythmia with exercise patterns in veteran male endurance athletes
  2. Pediatric Cardiology, 2021 -- Evaluating the Precision of Echocardiographic-Modified Task Force Criteria for Diagnosing Arrhythmogenic Ventricular Cardiomyopathy in Elite Adolescent Male Athletes
  3. European Journal of Preventive Cardiology, 2023 -- Cardiac magnetic resonance feature tracking in Olympic athletes: a myocardial deformation analysis
  4. European Journal of Preventive Cardiology, 2023 -- Enhancing Knowledge on Cardiac Remodeling Induced by Exercise: Insights into the Heart of Recreational Athletes
  5. Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria - PubMed, 2020
  6. Long-Term Risk Assessment in Athletes With Complex Ventricular Arrhythmias - PubMed, 2023
  7. Arrhythmogenic Cardiomyopathy or “Athlete’s Heart”?: A Systematic Approach to Differential Diagnosis | JACC: Clinical Electrophysiology, 2025
  8. Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria - PubMed
  9. Long-Term Risk Assessment in Athletes With Complex Ventricular Arrhythmias - PubMed
  10. Arrhythmogenic Cardiomyopathy or “Athlete’s Heart”?: A Systematic Approach to Differential Diagnosis | JACC: Clinical Electrophysiology

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