The quality of life in Ecuadorian patients with multiple sclerosis and neuromyelitis optica spectrum disorder and their association with anxiety, depression, fatigue, and disability - Report - MDSpire

The quality of life in Ecuadorian patients with multiple sclerosis and neuromyelitis optica spectrum disorder and their association with anxiety, depression, fatigue, and disability

  • By

  • Edgar Patricio Correa-Díaz

  • Ruth Jimbo-Sotomayor

  • Patricio Merino-Aguilera

  • May 1, 2026

  • 0 min

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Quality of Life Among Ecuadorian Individuals with MS and NMOSD

Overview

This study evaluates the quality of life (QoL) in Ecuadorian patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), highlighting significant differences in QoL, anxiety, depression, and fatigue between the two conditions. NMOSD patients exhibited a more compromised QoL and higher disability scores compared to MS patients.

Background

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are chronic autoimmune conditions that significantly impact patients' quality of life (QoL). Understanding the factors influencing QoL in these populations is crucial for improving patient care and management strategies. This study addresses a gap in research regarding QoL in NMOSD patients, particularly in the context of Latin America.

Data Highlights

ConditionQoL ScoreEDSS ScoreAnxiety LevelDepression LevelFatigue
MSLower QoLLower EDSSMildMildMore frequent
NMOSDMore compromised QoLHigher EDSSModerate/SevereMildLess frequent

Key Findings

  • QoL was significantly more compromised in NMOSD patients compared to MS patients (p < 0.005).
  • NMOSD patients had elevated EDSS scores compared to MS patients (p < 0.05).
  • Anxiety and depression were prevalent in both conditions, with NMOSD patients experiencing more severe anxiety.
  • Fatigue was observed more frequently in MS patients than in NMOSD patients (p < 0.01).
  • Younger NMOSD patients had lower QoL scores.
  • Correlations were found between disability, fatigue, anxiety, and depression with QoL in both MS and NMOSD patients.

Clinical Implications

Healthcare providers should be aware of the significant impact of anxiety, depression, and fatigue on the quality of life in patients with MS and NMOSD. Early identification and management of these psychological factors may improve patient outcomes and overall QoL. Tailored interventions addressing these issues are essential in clinical practice.

Conclusion

The study underscores the need for comprehensive care strategies that address both physical and psychological aspects of MS and NMOSD to enhance the quality of life for affected individuals.

References

  1. Frontiers in Neurology, 2026 -- Physical disability, cognition, and depression as determinants of quality of life in multiple sclerosis: a cross-sectional study
  2. Clinical Rheumatology, 2024 -- Impact of Self-Reported Anxiety and Depression on Health-Related Quality of Life in Individuals with Seropositive Rheumatoid Arthritis
  3. Clinical Rheumatology, 2006 -- Assessing Quality of Life in Patients with Rheumatic Disorders
  4. BMC Psychiatry, 2025 -- Impact of anxiety, depression and online mindfulness on IBD patients’ quality of life: a web-based cross-sectional survey and randomized pilot study
  5. PubMed, 2025 -- 2025 Brazilian guidelines for the management of neuromyelitis optica spectrum disorder in adults and children
  6. BMC Neurology, 2025 -- Comparative effectiveness of disease-modifying therapies for highly active relapsing-remitting multiple sclerosis despite previous treatment – a systematic review and network meta-analysis
  7. MDPI, 2023 -- Neuropathic Pain in Neuromyelitis Optica Spectrum Disorders: Prevalence and Management Strategies—A Systematic Review and Meta-Analysis
  8. 2025 Brazilian guidelines for the management of neuromyelitis optica spectrum disorder in adults and children - PubMed
  9. Comparative effectiveness of disease-modifying therapies for highly active relapsing-remitting multiple sclerosis despite previous treatment – a systematic review and network meta-analysis | BMC Neurology | Springer Nature Link
  10. Neuropathic Pain in Neuromyelitis Optica Spectrum Disorders: Prevalence and Management Strategies—A Systematic Review and Meta-Analysis

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