Upregulated CD177 on neutrophils is implicated in sepsis pathogenesis and necroptosis-driven inflammation - Report - MDSpire

Upregulated CD177 on neutrophils is implicated in sepsis pathogenesis and necroptosis-driven inflammation

  • By

  • Haibo Liu

  • Xiangshu Cheng

  • Jun Li

  • Wei Wei

  • Yijia Yuan

  • Wenjuan Wang

  • Wei Wang

  • Fang Liu

  • Jin Zheng

  • July 3, 2026

  • 0 min

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Clinical Report: Elevated CD177 Expression on Neutrophils Associated with Sepsis

Overview

This study identifies a six-gene necroptosis signature correlated with sepsis severity and outcomes, highlighting the role of CD177+ neutrophils in necroptosis-related inflammation.

Background

Sepsis is a critical condition characterized by organ dysfunction due to a dysregulated host response to infection, leading to high mortality rates. Understanding the mechanisms of sepsis, including necroptosis, is essential for developing innovative therapeutic strategies. The role of neutrophils in sepsis pathogenesis and their functional aberrations are pivotal in the inflammatory response associated with this condition.

Data Highlights

GeneExpression in Sepsis
CEBPDUpregulated
CEBPBUpregulated
MARCKSUpregulated
SOCS3Upregulated
PIM3Upregulated
JUNBUpregulated

Key Findings

  • Six-gene necroptosis signature correlates with sepsis severity and outcomes.
  • CD177+ neutrophils are enriched in non-surviving sepsis patients.
  • Machine learning models using the necroptosis signature show robust diagnostic performance.
  • CD177+ neutrophils exhibit heightened inflammatory mediator production.
  • Necroptosis activation correlates with IL-6/STAT3 and TNF-α/NF-κB pathways.

Clinical Implications

The identification of CD177+ neutrophils as contributors to necroptosis-related inflammation in sepsis is noted.

Conclusion

The study highlights a gene signature associated with sepsis. Further research is warranted.

Related Resources & Content

  1. Frontiers in Immunology, 2026 -- Neutrophil in sepsis: functional aberration and regulated cell death
  2. Critical Care (Springer), 2026 -- Plasma soluble CD147 levels in sepsis: the association with disease severity and the prediction for clinical outcome
  3. Critical Care, 2026 -- Neutrophil EMR3 dynamics in critically ill patients with sepsis: an ICU experience
  4. Intensive Care Medicine, 2008 -- 21st Annual Congress of the European Society of Intensive Care Medicine
  5. Surviving Sepsis Campaign, 2026 -- international guidelines for management of sepsis and septic shock
  6. Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial - PubMed, 2026
  7. Frontiers, 2026 -- Upregulated CD177 on neutrophils is implicated in sepsis pathogenesis and necroptosis-driven inflammation
  8. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026 | Intensive Care Medicine | Springer Nature Link
  9. Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial - PubMed
  10. Frontiers | Upregulated CD177 on neutrophils is implicated in sepsis pathogenesis and necroptosis-driven inflammation

Original Source(s)

Upregulated CD177 on neutrophils is implicated in sepsis pathogenesis and necroptosis-driven inflammation

  • by Haibo Liu, Xiangshu Cheng, Jun Li, Wei Wei, Yijia Yuan, Wenjuan Wang, Wei Wang, Fang Liu, Jin Zheng

  • July 3, 2026

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