Comparison of lattice and pipeline flow diverters for the treatment of distal intracranial aneurysms: an inverse probability of treatment weighting analysis - Report - MDSpire

Comparison of lattice and pipeline flow diverters for the treatment of distal intracranial aneurysms: an inverse probability of treatment weighting analysis

  • By

  • Shiqing Mu

  • Xinke Liu

  • Kaiyu Liu

  • Aoming Jin

  • Yan Zhao

  • Tian-Jie Lyu

  • Wenqi Hu

  • Yangyang Zhou

  • Qichen Peng

  • Xuanping Xie

  • Xiaoxi Zhu

  • Siyu Zhou

  • Jieran Huang

  • Xinjian Yang

  • July 9, 2026

  • 0 min

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Clinical Report: Evaluation of Lattice versus Pipeline Flow Diverters

Overview

This study compares the efficacy and safety of Lattice and Pipeline flow diverters in treating distal intracranial aneurysms. Both devices demonstrated similar aneurysm occlusion rates and complications.

Background

Distal intracranial aneurysms are challenging to treat due to their location and the risk of complications. Flow diverters have emerged as a treatment option, yet comparative data between different devices is limited.

Data Highlights

DeviceAneurysm Occlusion RateBranch Vessel Occlusion Rate
Lattice77.8%16.7%
Pipeline75.9%6.9%

Key Findings

  • No significant difference in aneurysm occlusion rates between Lattice (77.8%) and Pipeline (75.9%) devices (p = 0.586).
  • Branch vessel occlusion occurred in 16.7% of Lattice cases and 6.9% of Pipeline cases (p = 0.317).
  • The inflow angle (IFAA) was associated with delayed or incomplete aneurysm healing, with a 3.5% decrease in odds of occlusion per degree increase.
  • Larger aneurysm neck diameter and presence of branch vessel origin were linked to unfavorable outcomes.
  • Study included 47 patients treated between January 2020 and July 2025.
  • Follow-up imaging was conducted at a median of 179 days postoperatively.

Clinical Implications

The findings indicate that both Lattice and Pipeline flow diverters show similar efficacy and safety profiles.

Conclusion

Lattice and Pipeline flow diverters exhibit comparable efficacy and safety in managing distal cerebral aneurysms.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Frontiers in Neurology, 2026 -- Pilot feasibility study of intraprocedural transcranial Doppler monitoring to assess Heal coating thrombogenicity in flow diversion
  3. Frontiers in Neurology, 2026 -- Dual impact of flow diverters on ischemic and hemorrhagic outcomes in vertebral artery dissecting aneurysms presenting with ischemia
  4. AHA/ASA GUIDELINE, 2023 -- 2023 Guideline for the Management of Aneurysmal Subarachnoid Hemorrhage
  5. Evaluation of flow diverters for cerebral aneurysm therapy: recommendations for imaging analyses in clinical studies, endorsed by ESMINT, ESNR, OCIN, SILAN, SNIS, and WFITN - PMC
  6. Identifying Risk Factors for In-Stent Stenosis Following Flow-Diverter Placement in Patients with Intracranial Aneurysms: Insights from a Single-Center Study of 161 Cases
  7. Stroke AHA/ASA GUIDELINE 2023 Guideline for the Ma
  8. Evaluation of flow diverters for cerebral aneurysm therapy: recommendations for imaging analyses in clinical studies, endorsed by ESMINT, ESNR, OCIN, SILAN, SNIS, and WFITN - PMC
  9. Prospective study on embolization of intracranial aneurysms with the pipeline device: the PREMIER study 1 year results - PubMed
  10. Safety and efficacy of low profile flow diverter stents for intracranial aneurysms in small parent vessels: systematic review and meta-analysis - PubMed
  11. Comparison of PED Flex and Lattice flow diverter in the treatment of unruptured intracranial aneurysms - PMC

Original Source(s)

Comparison of lattice and pipeline flow diverters for the treatment of distal intracranial aneurysms: an inverse probability of treatment weighting analysis

  • by Shiqing Mu, Xinke Liu, Kaiyu Liu, Aoming Jin, Yan Zhao, Tian-Jie Lyu, Wenqi Hu, Yangyang Zhou, Qichen Peng, Xuanping Xie, Xiaoxi Zhu, Siyu Zhou, Jieran Huang, Xinjian Yang

  • July 9, 2026

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