Author Correction: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2 - Report - MDSpire

Author Correction: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

  • By

  • Selim Chaib

  • José Alberto López-Domínguez

  • Marta Lalinde-Gutiérrez

  • Neus Prats

  • Ines Marin

  • Olga Boix

  • Andrea García-Garijo

  • Kathleen Meyer

  • María Isabel Muñoz

  • Mònica Aguilera

  • Lidia Mateo

  • Camille Stephan-Otto Attolini

  • Susana Llanos

  • Sandra Pérez-Ramos

  • Marta Escorihuela

  • Fatima Al-Shahrour

  • Timothy P. Cash

  • Tamara Tchkonia

  • James L. Kirkland

  • María Abad

  • Alena Gros

  • Joaquín Arribas

  • Manuel Serrano

  • May 29, 2026

  • 0 min

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Correction: Intratumoral Senescent Cells Expressing PD-L2 Limit Chemotherapy

Overview

This correction addresses an error in the representation of images related to palbociclib treatments in SK-MEL-103 cells. The correct images have been included, and a new Source Data file has been prepared to reflect accurate experimental conditions.

Background

Understanding the role of immune checkpoint inhibitors, particularly PD-L2, in the context of chemotherapy is crucial.

Data Highlights

No numerical or trial data is presented in the correction article.

Key Findings

  • Correction made to the representative images for control and palbociclib treatments.
  • Images were mistakenly selected from a folder containing multiple experiments.
  • Corrected images are now included in the updated figure and Source Data file.
  • The error was identified during figure preparation.
  • New Source Data file reflects accurate experimental conditions from independent experiments.

Clinical Implications

Accurate representation of experimental data is essential for the interpretation of research findings.

Conclusion

The correction emphasizes the importance of data integrity in cancer research, particularly regarding the role of PD-L2 in chemotherapy effectiveness.

Related Resources & Content

  1. Llanos, S. et al, Oncogene, 2019 -- Mechanisms of PD-L2 in Cancer
  2. The ASCO Post — Chemotherapy-Induced Immunosuppressive Myeloid Cells Inhibit Tumor Control via PD-1–PD-L1 Axis
  3. The ASCO Post — Chemotherapy-Induced Immunosuppressive Myeloid Cells Inhibit Tumor Control via PD-1–PD-L1 Axis
  4. Frontiers in Oncology — PD-1 inhibitor combined with chemoradiotherapy in two cases of ovarian cancer brain metastases: a case report
  5. The ASCO Post — The Future of Immunotherapy: Building on Checkpoint Blockade
  6. Chemotherapy-Induced Immunosuppressive Myeloid Cells Inhibit Tumor Control via PD-1–PD-L1 Axis
  7. PD-1 inhibitor combined with chemoradiotherapy in two cases of ovarian cancer brain metastases: a case report
  8. Therapy for Stage IV Non–Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, 2026
  9. PD-L2 Landscape and Correlation with Outcome: An Immunomic Analysis - PMC
  10. Persistent accumulation of therapy-induced senescent cells: an obstacle to long-term cancer treatment efficacy | International Journal of Oral Science

Original Source(s)

Author Correction: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

  • by Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fatima Al-Shahrour, Timothy P. Cash, Tamara Tchkonia, James L. Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano

  • May 29, 2026

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