Link Between Bone Mineral Density and Coronary Artery Calcification: A Comprehensive Systematic Review and Meta-Analysis Update - Report - MDSpire
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Link Between Bone Mineral Density and Coronary Artery Calcification: A Comprehensive Systematic Review and Meta-Analysis Update

  • By

  • Xianghui Zeng

  • Dian Wang

  • Hao Yang

  • Zhenfang Liu

  • Xing Li

  • Ting Xiong

  • Ting Lu

  • Lu Dai

  • Feng Chen

  • March 7, 2026

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Clinical Report: Link Between Bone Mineral Density and Coronary Artery Calcification

Overview

This systematic review and meta-analysis updates the association between bone mineral density (BMD) and coronary artery calcification (CAC), revealing a potential link between lower BMD and higher CAC scores. The findings underscore the importance of understanding the shared biological pathways influencing both conditions.

Background

Bone mineral density decline and coronary artery calcification are significant age-related health issues, with osteoporosis affecting nearly 20% of older adults globally. CAC serves as a critical marker for subclinical atherosclerosis and cardiovascular risk. Understanding the relationship between BMD and CAC could enhance risk assessment and management strategies in older populations.

Data Highlights

No specific numerical data provided in the article.

Key Findings

Specify variations in the BMD-CAC association based on population characteristics.

Clinical Implications

Clinicians should consider the relationship between BMD and CAC when assessing cardiovascular risk in older patients. Screening for osteoporosis may be beneficial in populations at risk for both conditions, potentially guiding preventive strategies.

Conclusion

This updated meta-analysis reinforces the need for further research into the BMD-CAC relationship, highlighting its potential implications for cardiovascular risk management in older adults.

Related Resources & Content

  1. Zhang et al., European Journal of Preventive Cardiology, 2020 -- Link Between Bone Mineral Density and Coronary Artery Calcification
  2. Understanding the Development of Arterial Calcifications: Key Factors, Locations, and Affected Populations, European Radiology, 2023
  3. Association Between Low Bone Mineral Density and the Risk of Developing Liver Cirrhosis, The Journal of Clinical Endocrinology & Metabolism, 2025
  4. Recommendation: Osteoporosis to Prevent Fractures: Screening, United States Preventive Services Taskforce, 2025
  5. A comprehensive multi-layered analysis reveals genetic pleiotropy underlying coronary artery calcification and bone mineral density, ScienceDirect, 2025
  6. European Radiology — Evaluation of Osteoporosis Using Routine CT: Impact of Intravenous Contrast on Absolute Measurements, T-scores, and Classification Outcomes in Single and Dual-Energy Scans
  7. Osteoporosis Screening Recommendations
  8. A comprehensive multi-layered analysis reveals genetic pleiotropy underlying coronary artery calcification and bone mineral density - ScienceDirect
  9. Effect of osteoporosis medications on vascular and valvular calcification: a systematic review and meta-analysis - PubMed

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