Decision Moments and Pulmonary Embolism Diagnostic Quality in the Emergency Department - Report - MDSpire
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Critical Decision Points and the Quality of Pulmonary Embolism Diagnosis in Emergency Settings

  • By

  • Alexander T. Janke

  • Christopher M. Fung

  • Matthew C. Bombard

  • Seth Krupp

  • J. Adam Oostema

  • Daniel L. Overbeek

  • Matthew Hysell

  • James H. Paxton

  • Giuseppe Perrotta

  • Brett Todd

  • Lauren M. Westafer

  • Geoffrey D. Barnes

  • Colin F. Greineder

  • Keith E. Kocher

  • September 22, 2026

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Critical Decision Points and the Quality of Pulmonary Embolism Diagnosis in Emergency Settings

Background

Pulmonary embolism is a critical condition that is often underdiagnosed in emergency settings due to its nonspecific symptoms. Despite established guidelines and risk stratification tools, imaging for PE has significantly increased, raising concerns about overdiagnosis and associated risks. Understanding the decision-making process in PE diagnosis is essential.

Data Highlights

No numerical or trial data was provided in the source material.

Key Findings

  • ED clinicians often use risk-stratification tools like the Wells criteria and D-dimer assays to guide PE testing.
  • Imaging for PE has quadrupled over recent decades, despite evidence-based strategies aimed at reducing unnecessary tests.
  • The Pause Pre PE algorithm focuses on key decision moments to enhance the diagnostic yield of CTPA.
  • Standardizing testing protocols in EDs is challenging due to the need to balance overtesting with the risk of missed diagnoses.
  • MEDIC's quality improvement work promotes age-adjusted D-dimer interpretation as a strategy to optimize PE diagnosis.

Clinical Implications

Clinicians should be aware of the importance of structured decision-making frameworks in the diagnosis of PE to improve diagnostic quality. Implementing standardized protocols may help reduce unnecessary imaging while ensuring that at-risk patients receive timely and appropriate care.

Conclusion

Enhancing the quality of PE diagnosis in emergency settings requires a focus on clinician decision-making and the application of evidence-based risk stratification tools. Continued evaluation of diagnostic practices is essential for improving patient outcomes.

Related Resources & Content

  1. Frontiers in Medicine, 2026 -- Early Management and Successful thrombolysis in two Cases of High-Risk Pulmonary Embolism
  2. European Radiology, 2025 -- Revolutionizing Interventional Approaches and Collaborative Management in Acute Pulmonary Embolism
  3. Critical Care, 2026 -- Point-of-care ultrasound in hemodynamically unstable pulmonary embolism
  4. JACC, 2026 -- 2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults
  5. New England Journal of Medicine, 2019 -- Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability
  6. Vascular Medicine — Divergent PERTs: A call for unity via harmonized training programs
  7. 2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | JACC
  8. Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability | New England Journal of Medicine
  9. Optimal Approach to Performing and Reporting Computed Tomography Angiography for Suspected Acute Pulmonary Embolism: A Clinical Consensus Statement of the ESC Working Group on Pulmonary Circulation & Right Ventricular Function, the Fleischner Society, the Association for Acute Cardiovascular Care (ACVC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC, Endorsed by European Respiratory Society (ERS), Asian Society of Thoracic Radiology (ASTR), European Society of Thoracic Imaging (ESTI), and Society of Thoracic Radiology (STR) | Radiology

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