Clinical Report: Insights and Management Advances in Lymphoepithelial Carcinoma

Background

Lymphoepithelial carcinoma (LEC) is a rare malignant tumor of the salivary glands, accounting for approximately 0.4% of such tumors. Understanding its clinical characteristics and treatment approaches is crucial due to its complex etiology and the challenges in management. Current treatment strategies primarily involve surgical resection followed by radiotherapy.

Data Highlights

Key Findings

• LEC is primarily associated with the parotid gland, constituting a rare form of head and neck cancer.
• Two of the three reported cases exhibited cervical lymph node metastasis.
• Postoperative follow-up revealed no local recurrence or distant metastasis in two cases after 15 months.
• One case developed hepatic metastasis eight months post-radiotherapy, necessitating surgical intervention for the liver lesion.
• Current treatment strategies emphasize surgical resection followed by radiotherapy.

Clinical Implications

Surgical resection remains the cornerstone of treatment for lymphoepithelial carcinoma, with postoperative radiotherapy being a standard adjunct.

Conclusion

Lymphoepithelial carcinoma of the salivary gland presents significant management challenges, necessitating a combined treatment approach.

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4. Postoperative radiotherapy versus postoperative radiochemotherapy after surgery of salivary gland cancer: a systematic review and meta-analysis - PMC
5. Lymphoepithelial Carcinoma of the Salivary Gland: A Systematic Review and Single Institution Experience - Gibbs, 2026 - Otolaryngology–Head and Neck Surgery
6. Frontiers in Oncology — Case Report: A rare pediatric case of secretory carcinoma of the parotid gland with high-grade components misdiagnosed as pleomorphic adenoma
7. NCCN Head and Neck Cancers guideline
8. Postoperative radiotherapy versus postoperative radiochemotherapy after surgery of salivary gland cancer: a systematic review and meta-analysis - PMC
9. Lymphoepithelial Carcinoma of the Salivary Gland: A Systematic Review and Single Institution Experience - Gibbs - 2026 - Otolaryngology–Head and Neck Surgery - Wiley Online Library