Mpox Sequelae Persist 11 to 18 Months After Infection

Study supports follow-up and multidisciplinary care for persistent physical and psychosocial effects

By
Henry Thomas
January 27, 2026
3 min

Conexiant

Overview

A cohort study found that over half of adults evaluated 11 to 18 months post-mpox diagnosis had at least one persistent physical sequela, primarily mild appearance-related changes. Despite good overall health ratings, many participants reported ongoing social and sexual effects.

Background

Mpox, previously known as monkeypox, can lead to significant long-term sequelae following acute infection. Understanding these persistent effects is crucial for managing patient care and addressing the psychosocial impacts on individuals recovering from mpox. This study highlights the need for ongoing follow-up and support for affected patients.

Data Highlights

Finding	Percentage
Participants with at least one persistent sequela	58%
Appearance-related sequelae	56%
Participants reporting ongoing psychosocial challenges	~50%
Functional sequelae (anorectal/urinary symptoms)	13%
Participants with increased depressive symptoms	45%
Participants with ongoing effects on sexual performance	~20%

Key Findings

58% of participants had at least one persistent sequela 11 to 18 months post-infection.
56% of sequelae were appearance-related, with 83% reporting persistent skin discoloration.
13% of participants experienced functional complications, primarily anorectal or urinary dysfunction.
45% reported increased depressive symptoms, and 40% reported increased anhedonia.
Persistent sequelae were linked to more severe acute disease, particularly confluent lesions.
Persistent sequelae were not associated with uncontrolled HIV or prior vaccination.

Clinical Implications

Healthcare providers should be aware of the potential for long-term sequelae in patients recovering from mpox, including psychosocial impacts. Regular follow-up assessments are recommended to address persistent symptoms and support overall health and well-being.

Conclusion

The findings underscore the importance of long-term monitoring for individuals recovering from mpox, as many experience lasting physical and psychosocial challenges. Continued research and support are essential for this patient population.