Retraction Note: TWIST1 activates cancer stem cell marker genes to promote epithelial‑mesenchymal transition and tumorigenesis in esophageal squamous cell carcinoma - Report - MDSpire
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Correction Notice: TWIST1's Role in Activating Cancer Stem Cell Markers and Facilitating Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma

  • By

  • Sima Ardalan Khales

  • Sina Mozaffari‑Jovin

  • Dirk Geerts

  • Mohammad Reza Abbaszadegan

  • September 11, 2026

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Correction Notice: TWIST1's Role in Activating Cancer Stem Cell Markers

Overview

The article discussing TWIST1's role in esophageal squamous cell carcinoma has been retracted due to concerns about data integrity. The Editors lost confidence in the article's findings after identifying similarities in presented data for different cell lines.

Background

Esophageal squamous cell carcinoma (ESCC) is a significant health concern with complex biological mechanisms, including epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) markers.

Data Highlights

No numerical or trial data is available due to the retraction of the article.

Key Findings

  • The article was retracted due to concerns about data integrity.
  • Similarities were identified in the data presented for different cell lines.
  • The authors did not respond to the concerns raised by the Editors.
  • The retraction affects the confidence in the conclusions drawn regarding TWIST1's role in ESCC.
  • Related articles emphasize the importance of accurate data in cancer research.

Clinical Implications

The retraction of this article highlights the importance of data integrity in cancer research.

Conclusion

The retraction of the article emphasizes the need for data verification in cancer research.

Related Resources & Content

  1. BMC Cancer, 2022 -- Correction Notice: TWIST1's Role in Activating Cancer Stem Cell Markers
  2. Frontiers in Medicine — Correction: STC1 promotes colorectal cancer invasion and migration by regulating M2 macrophage polarization via TGF-β1/Smad signaling pathway
  3. the asco post — Advanced Esophageal Cancer: NOTCH1 Mutation and Efficacy of Tislelizumab
  4. the pathologist — Research Timeline
  5. Blood Cancer Journal — The Growing Significance of Twist Proteins in Hematopoietic Cells and Blood Cancers
  6. Correction: STC1 promotes colorectal cancer invasion and migration
  7. Advanced Esophageal Cancer: NOTCH1 Mutation and Efficacy of Tislelizumab
  8. Research Timeline
  9. SEOM–GEMCAD–TTD clinical guideline for the diagnosis and treatment of esophageal cancer (update 2025)
  10. label

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