Associations of seminal plasma metal mixtures with sperm quality parameters and exploratory mediation analysis of urinary oxidative stress biomarkers: a cross-sectional study from the RHCC-AC preconception cohort - Report - MDSpire
Advertisement
Associations of seminal plasma metal mixtures with sperm quality parameters and exploratory mediation analysis of urinary oxidative stress biomarkers: a cross-sectional study from the RHCC-AC preconception cohort
Linkages Between Metal Mixtures in Seminal Plasma and Sperm Quality Metrics
Overview
This study investigates the associations between metal mixtures in seminal plasma and various sperm quality metrics. Aluminum and cobalt were identified as significant contributors to sperm abnormalities and reduced motility.
Background
The decline in semen quality is a growing concern, with male factors contributing to infertility in a substantial number of couples. Environmental exposure to metals has been implicated in impaired sperm quality. This study aims to elucidate the relationships between metal exposure and sperm quality.
Data Highlights
Metal
Association
Effect
Aluminum (Al)
Sperm abnormality rate
Positive
Cobalt (Co)
Total motility
Negative
Arsenic (As), Iron (Fe), Selenium (Se)
Sperm concentration
Positive
Key Findings
Aluminum was positively associated with sperm abnormality rate.
Cobalt and copper were inversely associated with progressive and total motility.
Arsenic, iron, and selenium were positively associated with sperm concentration.
D,L-ortho-tyrosine mediated the associations of mercury and vanadium with sperm concentration.
Aluminum and cobalt were identified as primary contributors to sperm quality metrics.
Clinical Implications
Understanding the impact of environmental metal exposure on sperm quality may inform clinical evaluations of male infertility.
Conclusion
The study highlights significant associations between metal mixtures in seminal plasma and sperm quality.
