Clinical Report: Evaluating the Role of Early Nutritional and Immune Status Assessment

Overview

This study investigates the association between the HALP score and all-cause mortality in patients with intracerebral hemorrhage (ICH). A lower HALP score correlates with increased mortality risk.

Background

Intracerebral hemorrhage (ICH) accounts for a significant proportion of stroke-related deaths, necessitating effective prognostic tools. The systemic status of ICH patients, including nutritional and immune factors, is increasingly recognized as critical to outcomes. The HALP score integrates these factors, offering a comprehensive assessment of patient risk.

Data Highlights

Key Findings

• The HALP score is associated with increased mortality in ICH patients.
• Patients in the Q1 group (HALP < 16.87) had significantly higher mortality rates (p < 0.001).
• Kaplan–Meier survival curves and RCS regression analysis confirmed the non-linear correlation between HALP score and mortality risk.
• The risk model based on nutritional assessment effectively identifies high-risk ICH patients.
• The nomogram achieved an AUROC of 0.825 in the internal cohort, indicating strong predictive capability.

Clinical Implications

Clinicians may utilize the HALP score as a prognostic tool to identify high-risk ICH patients. This score can aid in stratifying patients for more intensive monitoring and intervention strategies.

Conclusion

The study indicates an association between the HALP score and mortality in ICH patients.

Related Resources & Content

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5. European Stroke Organisation, ESO and EANS guideline on stroke due to spontaneous intracerebral haemorrhage, 2025
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