Malignant transformation of uterine serosal endometriosis to clear cell carcinoma in a postmenopausal patient: a rare case report - Report - MDSpire

Malignant transformation of uterine serosal endometriosis to clear cell carcinoma in a postmenopausal patient: a rare case report

  • By

  • Xiaodong Mi

  • Tong Lin

  • Xiaogang Zhu

  • Qian Chen

  • Xihan Yang

  • Purun Zou

  • Dan Shu

  • Fei Tuo

  • June 17, 2026

  • 0 min

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Clinical Report: Rare Case of Clear Cell Carcinoma Arising from Uterine Serosal Endometriosis

Overview

This report presents a rare case of clear cell carcinoma arising from endometriosis on the uterine serosa in a postmenopausal woman. The case highlights the potential for malignant transformation in atypical endometriosis locations, emphasizing the need for awareness and further investigation.

Background

Endometriosis is a common benign condition that can lead to chronic inflammation and is often associated with an increased risk of ovarian malignancies. In postmenopausal women, the risk of malignant transformation from endometriosis rises significantly, yet cases involving the uterine serosa are exceedingly rare. Understanding these rare occurrences is crucial for improving diagnostic and treatment strategies.

Data Highlights

No numerical data or trial data available in the article.

Key Findings

['A 62-year-old postmenopausal woman presented with dull lower abdominal pain.', 'Imaging suggested a possible left ovarian tumor, but pathology confirmed clear cell carcinoma from uterine serosal endometriosis.', 'The surgical intervention included total hysterectomy and bilateral adnexal resection.', 'Postoperative follow-up showed no abnormalities after six months.', 'This case illustrates the coexistence of benign and malignant components in endometriosis.']

Clinical Implications

Healthcare professionals should maintain a high index of suspicion for malignant transformation in postmenopausal women with a history of endometriosis. Early recognition and appropriate surgical management are essential for improving patient outcomes in such rare cases.

Conclusion

This case underscores the rarity of clear cell carcinoma arising from uterine serosal endometriosis and highlights the need for further research into the mechanisms of malignant transformation in endometriosis.

Related Resources & Content

  1. Frontiers in Medicine, 2026 -- Mesonephric-like adenocarcinoma of the uterine corpus: a case report
  2. Frontiers in Oncology, 2026 -- Case Report: Intramyometrial Uterine Large-Cell Neuroendocrine Carcinoma Mimicking Adenomyosis and Leiomyomas With Rapid Fatal Relapse
  3. Frontiers in Oncology, 2026 -- Case Report: Cardiac metastasis of sarcomatoid urothelial carcinoma
  4. New Evidence About Malignant Transformation of Endometriosis—A Systematic Review - PMC
  5. Diagnosis of Endometriosis | ACOG, 2026
  6. Frontiers in Oncology — Synchronous primary breast invasive carcinoma and breast metastasis from high-grade serous ovarian carcinoma: a case report and literature review
  7. New Evidence About Malignant Transformation of Endometriosis—A Systematic Review - PMC
  8. Diagnosis of Endometriosis | ACOG
  9. https://www.esgo.org/media/2025/08/Pocket-Guidelines_Ovarian-cancer-consensus.pdf

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