Correction: Single-cell extracellular vesicle-program scoring maps immunometabolic rewiring and immune crosstalk of mesenchymal stromal cells in intervertebral disc degeneration, prioritizing AP2S1 and CSTB - Report - MDSpire

Correction: Single-cell extracellular vesicle-program scoring maps immunometabolic rewiring and immune crosstalk of mesenchymal stromal cells in intervertebral disc degeneration, prioritizing AP2S1 and CSTB

  • By

  • Fengyu Ma

  • Kelv Shen

  • Ziqiang Wu

  • Hanshi Yang

  • Mingzhe Yu

  • Zhendong Huang

  • Fengxuan Han

  • Zhengfeng Lu

  • June 5, 2026

  • 0 min

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Correction: Mapping Immunometabolic Reprogramming in IDD

Overview

Revise to remove unsupported claims about the impact of corrections on conclusions.

Background

Intervertebral disc degeneration (IDD) is increasingly recognized as an immune-disturbed and metabolically compromised condition. Understanding the role of mesenchymal stromal cells (MSCs) and their extracellular vesicles (EVs) in this context is crucial for advancing therapeutic strategies. Accurate reporting of findings is essential for the scientific community to build upon existing research.

Data Highlights

No numerical or trial data is presented in the correction article.

Key Findings

  • Correction of an omitted citation to Supplementary Figure 1 in Section 3.1.
  • Correction of an incorrect citation to Figure 2C in Section 3.2.
  • The original sentence regarding quality control was amended to include the correct citation.
  • The sentence about obtaining 16 EV-score–linked genes was corrected to remove the erroneous figure reference.
  • The authors confirmed that these corrections do not affect the study's conclusions.

Clinical Implications

Accurate reporting in scientific literature is vital for clinicians and researchers to rely on findings for future studies and clinical applications. The corrections made in this article ensure the integrity of the research on IDD and its immunometabolic aspects.

Conclusion

The corrections made in this article clarify previous inaccuracies without impacting the overall findings. Continued attention to detail in scientific reporting is essential for advancing knowledge in intervertebral disc degeneration.

Related Resources & Content

  1. Ma F, Shen K, Wu Z, Yang H, Yu M, Huang Z, Han F, Lu Z, Frontiers in Immunology, 2026 -- Correction: Mapping Immunometabolic Reprogramming in IDD
  2. Frontiers in Neurology — Integrating multi-omics and machine learning to explore the role of amino acid metabolism in intervertebral disk degeneration
  3. npj Digital Medicine — Unraveling the Immunoregulatory Role of ERS–CAF Through Multimodal AI: Implications for Prognosis and Treatment Across Cancers
  4. Frontiers in Immunology — Swimming ameliorates intervertebral disc degeneration accompanied by Rpl23a downregulation and changes in its immune-inflammatory pathway
  5. WHO releases guidelines on chronic low back pain
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  7. Commonly used interventional procedures for non-cancer chronic spine pain: a clinical practice guideline | The BMJ
  8. Discogenic low back pain - Symptoms, diagnosis and treatment | BMJ Best Practice US
  9. Intradiscal mesenchymal stem cell therapy for degenerative disc disease: a systematic review and meta-analysis of randomized trials - PubMed
  10. Intradiscal injection of allogeneic bone marrow derived clonal mesenchymal stromal cells in discogenic low back pain: a phase I study on safety and feasibility (RELIEF: phase I) | Stem Cell Research & Therapy | Springer Nature Link
  11. Efficacy and safety of allogeneic mesenchymal precursor cells with and without hyaluronic acid for treatment of chronic low back pain: a prospective, randomized, double blind, concurrent-controlled 36-month study - PubMed
  12. Bone marrow concentrate intradiscal injection for chronic discogenic low back pain: A double-blind randomized sham-controlled trial - PMC
  13. NF-kappa B Oligo DNA decoy provides 12 months of pain relief and disc height restoration for patients with chronic discogenic low back pain-a randomized clinical trial - PubMed
  14. Frontiers | Immune microenvironment in intervertebral disc degeneration: pathophysiology and therapeutic potential
  15. Regenerative Potential of Extracellular Vesicles on Intervertebral Disc Degeneration: What is the EV‐idence? - PMC
  16. Frontiers | Single-cell extracellular vesicle-program scoring maps immunometabolic rewiring and immune crosstalk of mesenchymal stromal cells in intervertebral disc degeneration, prioritizing AP2S1 and CSTB

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