Multidisciplinary surgery for intravenous leiomyomatosis with inferior vena cava and/or intracardiac extension: a case series - Report - MDSpire

Multidisciplinary surgery for intravenous leiomyomatosis with inferior vena cava and/or intracardiac extension: a case series

  • By

  • Feifeng Lin

  • Xia Liu

  • Bingqing Huang

  • Yunhong Lei

  • Jianjie Huang

  • Shuo Chen

  • Qiuling Fan

  • Zheng Chen

  • Minghong Shen

  • July 15, 2026

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Clinical Report: Surgical Management of Intravenous Leiomyomatosis

Overview

This study analyzes the clinical characteristics and surgical outcomes of five patients with intravenous leiomyomatosis extending into the inferior vena cava and/or heart.

Background

Intravenous leiomyomatosis is a rare benign tumor that can extend along venous systems, potentially leading to severe clinical consequences. Its involvement with the inferior vena cava and heart poses significant surgical challenges.

Data Highlights

ParameterValue
Median Age46.0 years
Common SymptomsPelvic/intracardiac masses (80%), abdominal distension (20%)
Blood Loss800 mL (450–4,600 mL)
Postoperative Complications60% pulmonary/pelvic infections, 20% incomplete intestinal obstruction
Follow-up Duration30 months (14–74 months)

Key Findings

  • All patients had a history of uterine fibroids or related hysterectomy.
  • 60% of patients had concomitant intracardiac tumors.
  • One patient had ovarian vein masses.
  • Complete tumor resection was achieved in all cases.
  • No recurrence was observed during the median follow-up period.

Clinical Implications

Surgical management of intravenous leiomyomatosis with inferior vena cava and/or heart extension requires careful preoperative assessment and surgical planning.

Conclusion

Intravenous leiomyomatosis involving major vascular structures is rare and complex.

Related Resources & Content

  1. Fuzhou University Affiliated Provincial Hospital, 2024 -- Surgical Management of Intravenous Leiomyomatosis
  2. Journal of Gastrointestinal Surgery — Surgical Approach to Retroperitoneal Leiomyosarcoma Originating from the Inferior Vena Cava
  3. Frontiers in Cardiovascular Medicine — Intravenous leiomyomatosis manifesting as a cardiac mass: a case report
  4. Utilization of Left Renal Vein Graft and In Situ Hepatic Perfusion During Hepatectomy for Tumors Invading Hepatic Veins: Enhancing Hemodynamics and Surgical Approach
  5. Frontiers in Oncology — A rare and massive retroperitoneal leiomyoma: a case report
  6. Surgical Management of Tumours Invading the Inferior Vena Cava: A Delphi Consensus Document
  7. Management of intravenous leiomyomatosis: a comprehensive review of surgical and perioperative considerations
  8. Multidisciplinary management of intravenous leiomyomatosis extending to the inferior vena cava and heart: a case series - PubMed

Original Source(s)

Multidisciplinary surgery for intravenous leiomyomatosis with inferior vena cava and/or intracardiac extension: a case series

  • by Feifeng Lin, Xia Liu, Bingqing Huang, Yunhong Lei, Jianjie Huang, Shuo Chen, Qiuling Fan, Zheng Chen, Minghong Shen

  • July 15, 2026

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