Lipidomics of HIV/HCV-related liver decompensation: association between plasma lipid depletion and immune dysregulation - Report - MDSpire

Lipidomics of HIV/HCV-related liver decompensation: association between plasma lipid depletion and immune dysregulation

  • By

  • Raquel Behar-Lagares

  • Belen Requena

  • Juan Berenguer

  • Ana Virseda-Berdices

  • Juan Gónzalez-García

  • Carolina Gonzalez-Riano

  • Cristina Díez

  • Victor Hontañón

  • Aida Vaquero-Rey

  • Coral Barbas

  • Salvador Resino

  • Rubén Martín-Escolano

  • María Ángeles Jiménez-Sousa

  • June 30, 2026

  • 0 min

Share

Lipidomic Analysis of Liver Decompensation in HIV/HCV Coinfection

Overview

This study identifies a significant depletion of plasma lipids in HIV/HCV-coinfected patients with decompensated advanced chronic liver disease (dACLD).

Background

Chronic hepatitis C can progress to compensated advanced chronic liver disease (cACLD) and further to decompensated ACLD (dACLD), which is associated with increased liver-related mortality. The presence of HIV coinfection accelerates this progression.

Data Highlights

No numerical data or trial data presented in the article.

Key Findings

  • A signature of 28 lipids was identified as significantly depleted in patients with dACLD.
  • The depleted lipids included phosphatidylcholines, phosphatidylethanolamines, and triglycerides.
  • 17.2% of the cohort was classified as having dACLD.
  • Lipid depletion correlated with the pro-inflammatory chemokine IP-10.
  • Systemic lipid dysregulation is linked to immune activation in the context of liver decompensation.

Clinical Implications

The identification of lipidomic profiles associated with dACLD may aid in the development of biomarkers for predicting disease progression in HIV/HCV-coinfected patients.

Conclusion

The study highlights the role of lipid dysregulation in the pathogenesis of liver decompensation in HIV/HCV-coinfected patients.

Related Resources & Content

  1. The Journal of Infectious Diseases, 2023 -- Changes in the Lipidome Are Associated With Immune Activation and Subclinical Vascular Disease in Youth With Human Immunodeficiency Virus in Uganda
  2. Frontiers in Immunology, 2026 -- Integrated multi-omics identifies CRP as a prognostic biomarker and reveals complement consumption in HIV-associated AECOPD
  3. The Journal of Infectious Diseases, 2023 -- Human Immunodeficiency Virus–Associated Proteomic Signature of Myocardial Fibrosis and Incident Heart Failure
  4. Open Forum Infectious Diseases, 2023 -- Evaluation of Liver Fibrosis Change After DAA-induced Cure of Hepatitis C in Participants With and Without HIV: ACTG A5320 Viral Hepatitis C Infection Long-term Cohort Study (VHICS)
  5. Persons With HIV/HCV Coinfection – HCV Guidance, 2026
  6. Persons With HIV/HCV Coinfection – HCV Guidance
  7. Lipid metabolism disturbance and immune dysfunction in HBV-related acute-on-chronic liver failure: a retrospective cohort study

Original Source(s)

Lipidomics of HIV/HCV-related liver decompensation: association between plasma lipid depletion and immune dysregulation

  • by Raquel Behar-Lagares, Belen Requena, Juan Berenguer, Ana Virseda-Berdices, Juan Gónzalez-García, Carolina Gonzalez-Riano, Cristina Díez, Victor Hontañón, Aida Vaquero-Rey, Coral Barbas, Salvador Resino, Rubén Martín-Escolano, María Ángeles Jiménez-Sousa

  • June 30, 2026

Related Content

Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis

INVA8001, a novel and highly selective chymase inhibitor, ameliorates liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice

Frontiers and emerging trends in research on metabolic syndrome and metabolic dysfunction-associated fatty liver disease: a bibliometric analysis (2005-2024)