Correction of Visual Abstract in Clinical Trial on Neonatal Sepsis and Barrier Precautions
Background
Neonatal sepsis remains a significant cause of morbidity and mortality in critically ill infants, particularly those in neonatal intensive care units (NICUs). The BALTIC trial provides insights into the comparative effectiveness of extended barrier precautions versus standard hand hygiene.
Data Highlights
| Outcome | Extended Barrier Precautions | Hand Hygiene Alone | Risk Difference |
|---|---|---|---|
| Gram-negative bloodstream infection | 22/4,699 (0.5%) | 25/5,032 (0.5%) | −0.03% (95% CI, −0.43% to 0.38%) |
| Months with transmission of resistant bacteria | 41/144 | 54/144 | −9.03% (95% CI, −27.79% to 9.74%) |
| Total BSI rates | 2.1% | 2.0% | 0.12% (95% CI, −1.39% to 1.64%) |
Key Findings
- The risk difference for gram-negative bloodstream infection was 0.03%; 95% CI, 0.43% to 0.38%.
- Standard hand hygiene was found to be noninferior to extended barrier precautions in the BALTIC trial.
- Transmission of third-generation cephalosporin-resistant gram-negative bacteria occurred in fewer months with standard hand hygiene.
- Total bloodstream infection rates were similar between the two groups.
Clinical Implications
Accurate reporting of trial data is essential for clinicians to make informed decisions regarding infection control practices in NICUs.
Conclusion
The correction of the visual abstract in the BALTIC trial is vital for ensuring the integrity of the data presented.
Related Resources & Content
- JAMA Network Open, 2026 -- Errors in Abstract, Results, Table 1, Table 2, Table 3, Discussion, and Visual Abstract
- JAMA Network Open, 2026 -- Extended Barrier Precautions vs Hand Hygiene Alone and Neonatal Sepsis in Intensive Care Patients: The BALTIC
- JAMA Network Open, 2026 -- Antiseptic Cleansing to Reduce Vertical Transmission of Pathogens to Neonates: The NeoVT-AMR Randomized
- CDC, 2023 -- Recommendations | Infection Control
- Pediatric Cardiology — Correction: Navigating the Shift from In-Utero Safety to External Environment for Infants with Critical Cardiovascular Disorders: The IMmediate Postpartum Access to Cardiac Therapy (IMPACT) Approach
- CDC Isolation Precautions
- BALTIC Cluster-Randomized Clinical Trial
- HICPAC November 2024 Meeting Update - APIC
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