Passenger lymphocyte syndrome following organ and stem cell transplantation: current insights and clinical implications - Report - MDSpire

Passenger lymphocyte syndrome following organ and stem cell transplantation: current insights and clinical implications

  • By

  • Zhong-yu Kang

  • Xue-ya Han

  • Chun Liu

  • Wei Liu

  • Dai-hong Li

  • June 11, 2026

  • 0 min

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Clinical Report: Understanding Passenger Lymphocyte Syndrome in Transplants

Overview

Passenger lymphocyte syndrome (PLS) is an alloimmune complication occurring in ABO-mismatched organ and stem cell transplants, characterized by donor-derived B lymphocytes producing antibodies against recipient red blood cell antigens. The incidence of PLS varies significantly across different organ transplants, with management strategies often being case-specific.

Background

Remove unsupported claims about improving patient outcomes and developing standardized management protocols.

Data Highlights

Organ TypeReported Incidence
Kidney~9%
Liver30-40%
LungOver 50%

Key Findings

Revise to remove unsupported conclusions about mortality and transfusion support.

Clinical Implications

Remove recommendations and clinical implications not supported by the source material.

Conclusion

Omit unsupported claims about the need for further research and standardized management approaches.

Related Resources & Content

  1. Bone Marrow Transplantation, 2026 -- Early high-resolution immune profiles are associated with survival, relapse and graft-versus-host-disease after allogeneic hematopoietic cell transplantation
  2. The ASCO Post, 2016 -- Reduced-Intensity Related-Donor Haploidentical vs HLA-Matched Sibling-Donor Hematopoietic Cell Transplantation in Lymphoma
  3. Bone Marrow Transplantation, 2014 -- Severe Chronic Psychosis Following Allogeneic Stem Cell Transplantation from a Sibling Diagnosed with Schizophrenia
  4. The ASCO Post, 2019 -- Allogeneic Hematopoietic Cell Transplantation and Cell Therapy
  5. Transfusion Support - The EBMT Handbook - NCBI Bookshelf
  6. Passenger lymphocyte syndrome (PLS) overview
  7. Transfusion Support - The EBMT Handbook - NCBI Bookshelf

Original Source(s)

Passenger lymphocyte syndrome following organ and stem cell transplantation: current insights and clinical implications

  • by Zhong-yu Kang, Xue-ya Han, Chun Liu, Wei Liu, Dai-hong Li

  • June 11, 2026

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