Systemic immune-inflammation index predicts post-thrombectomy outcomes and reveals a mediating role in the association between neurocardiac stress and prognosis: a multicenter study - Report - MDSpire

Systemic immune-inflammation index predicts post-thrombectomy outcomes and reveals a mediating role in the association between neurocardiac stress and prognosis: a multicenter study

  • By

  • Long Yang

  • Han Zhao

  • Qingtao Xie

  • Qitong Chen

  • Yehong Liu

  • Hailiang Li

  • Jun Lu

  • Bo Du

  • Jiheng Hao

  • Jiyou Yu

  • Chao Sun

  • Yu Liu

  • Yujia Zhai

  • Haibing Liao

  • Yiming Yin

  • Hui Chen

  • Qiuchen Zhao

  • Yu Feng

  • May 29, 2026

  • 0 min

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Clinical Report: Systemic Immune-Inflammation Index as a Predictor of Outcomes Following Thrombectomy

Overview

This study investigates the role of the Systemic Immune-Inflammation Index (SII) in predicting outcomes after endovascular thrombectomy (EVT) for stroke patients.

Background

Systemic inflammation and neurocardiac stress are critical factors influencing recovery after EVT for acute ischemic stroke.

Data Highlights

OutcomePercentage
Poor outcome in derivation cohort56.1% (289/515)
Adjusted OR for AF-RVR and high SII9.80 (95% CI, 3.46–31.43)
AUC for model discrimination (derivation)0.789
AUC for model discrimination (validation)0.710

Key Findings

  • Poor outcomes occurred in 56.1% of the EVT patients in the derivation cohort.
  • AF-RVR was associated with elevated SII levels.
  • Patients with both AF-RVR and high SII had a significantly increased risk of poor outcomes (adjusted OR 9.80).
  • The mediation analysis indicated a significant indirect effect of AF-RVR on outcomes via SII (absolute risk difference 4.6 percentage points).
  • The developed nomogram demonstrated good discrimination and clinical utility for predicting post-EVT outcomes.

Clinical Implications

The integration of SII and AF-RVR into prognostic models may enhance individualized risk assessment for patients undergoing EVT.

Conclusion

The study developed and validated a nomogram that incorporates systemic inflammation and neurocardiac stress to predict outcomes after EVT.

Related Resources & Content

  1. Frontiers in Neurology, 2026 -- Prognostic value of systemic inflammation response index in successfully recanalized acute large vessel occlusion stroke patients: a retrospective study
  2. Frontiers in Cardiovascular Medicine, 2026 -- Systemic inflammatory indexes mediate cardiac injury following intracerebral hemorrhage
  3. Clinical Research in Cardiology, 2018 -- Association of Plasma Interleukin 6 Concentrations with Cardiac Function Following ST-Elevation Myocardial Infarction
  4. Large-Core Ischemic Stroke Endovascular Treatment: A Science Advisory From the American Heart Association, 2024
  5. Systemic Inflammatory Response Index and the Short-Term Functional Outcome of Patients with Acute Ischemic Stroke: A Meta-analysis, 2024
  6. Clinical Research in Cardiology — Impact of Coronary No-Reflow on Clinical Outcomes in Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention with Modern Drug-Eluting Stents and Third-Generation P2Y12 Inhibitors
  7. Large-Core Ischemic Stroke Endovascular Treatment: A Science Advisory From the American Heart Association - PubMed
  8. Systemic Inflammatory Response Index and the Short-Term Functional Outcome of Patients with Acute Ischemic Stroke: A Meta-analysis - PubMed
  9. Elevated troponin levels as a predictor of mortality in patients with acute stroke: a systematic review and meta-analysis - PubMed

Original Source(s)

Systemic immune-inflammation index predicts post-thrombectomy outcomes and reveals a mediating role in the association between neurocardiac stress and prognosis: a multicenter study

  • by Long Yang, Han Zhao, Qingtao Xie, Qitong Chen, Yehong Liu, Hailiang Li, Jun Lu, Bo Du, Jiheng Hao, Jiyou Yu, Chao Sun, Yu Liu, Yujia Zhai, Haibing Liao, Yiming Yin, Hui Chen, Qiuchen Zhao, Yu Feng

  • May 29, 2026

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