Determinants of de novo aneuploidy in various preimplantation genetic testing cycles
Overview
This study identifies advanced maternal age and blastocyst expansion degree as significant predictors of de novo aneuploidy in preimplantation genetic testing cycles. The findings highlight the importance of individualized risk assessment in embryo selection across different patient cohorts.
Background
Aneuploidy is a leading cause of early pregnancy loss and is associated with various reproductive challenges, including implantation failure and miscarriage. Understanding the determinants of aneuploidy is crucial for improving outcomes in assisted reproductive technology (ART). This study provides insights into how maternal and embryonic factors contribute to aneuploidy rates in preimplantation genetic testing.
Data Highlights
PGT Type
Aneuploidy Rate
PGT-SR
19.5%
PGT-A
32.1%
PGT-M
31.2%
Key Findings
Advanced maternal age (≥35 years) is a robust predictor of de novo aneuploidy.
Blastocyst expansion degree is significantly associated with aneuploidy in both PGT-SR and PGT-A cohorts.
In the PGT-A cohort, maternal age, AMH levels, ICM grade, and TE grade are significant predictors of aneuploidy.
TE grade is particularly correlated with aneuploidy in women aged ≥30 years in the PGT-M cohort.
No independent effects were found for semen parameters or stimulation protocols across any cohort.
Clinical Implications
Clinicians should consider advanced maternal age and blastocyst expansion degree when assessing the risk of aneuploidy in patients undergoing preimplantation genetic testing. These findings support the need for tailored embryo selection strategies to improve reproductive outcomes.
Conclusion
The study underscores the significance of maternal age and embryonic characteristics in predicting de novo aneuploidy, advocating for personalized approaches in preimplantation genetic testing.
