Inverse association of circulating kallikrein-related peptidase 7 with renal function and mortality risk in patients with chronic kidney disease - Report - MDSpire

Inverse association of circulating kallikrein-related peptidase 7 with renal function and mortality risk in patients with chronic kidney disease

  • By

  • Robin Schürfeld

  • Fabian Baalmann

  • Ekaterine Baratashvili

  • Benjamin Sandner

  • Anette Bachmann

  • Juliane Weiner

  • Marleen Würfel

  • Ralph Wendt

  • Martin Haussmann

  • Ingolf Bast

  • Joachim Beige

  • Joanna Kosacka

  • Nora Klöting

  • Knut Krohn

  • Toralf Kirsten

  • Ming-Zhi Zhang

  • Raymond C. Harris

  • Berend Isermann

  • Peter Kovacs

  • Matthias Blüher

  • Michael Stumvoll

  • Anke Tönjes

  • John T. Heiker

  • Thomas Ebert

  • July 7, 2026

  • 0 min

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Association of Serum Kallikrein-Related Peptidase 7 Levels with Renal Function and Mortality Risk in Chronic Kidney Disease Patients

Overview

This study investigates the relationship between serum KLK7 levels and renal function as well as mortality risk in chronic kidney disease (CKD) patients. Higher KLK7 levels were found to be inversely associated with renal function over a median follow-up of 7.6 years.

Background

Chronic kidney disease (CKD) is a significant global health issue, contributing to approximately 1.2 million deaths annually. The disease is often asymptomatic until advanced stages, necessitating the identification of biomarkers that can reflect renal pathology and associated comorbidities.

Data Highlights

OutcomeAdjusted HR (95% CI)p-value
All-cause mortality0.65 (0.49–0.86)0.003
Non-cardiovascular mortality0.56 (0.40–0.78)0.001

Key Findings

  • KLK7 levels inversely associated with estimated glomerular filtration rate (eGFR) and C-reactive protein.
  • Higher baseline KLK7 levels predict lower all-cause mortality in CKD patients.
  • A KLK7 threshold of 1383.6 pg/ml stratified patients into low- and high-risk mortality groups.
  • No significant associations were found between KLK7 levels and major adverse renal or cardiovascular events.
  • mRNA expression of Klk7 did not show significant changes in CKD versus control mice.

Clinical Implications

Monitoring KLK7 levels may provide information regarding renal function in CKD patients.

Conclusion

The study investigates KLK7 levels in relation to renal function and mortality risk in CKD.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Author(s)/Org, Source, Year -- Title
  3. Author(s)/Org, Source, Year -- Title
  4. Author(s)/Org, Source, Year -- Title
  5. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease
  6. Long-Term Effects of Empagliflozin in Patients with Chronic Kidney Disease | New England Journal of Medicine
  7. Prognostic value of neutrophil-to-lymphocyte ratio for the clinical outcomes of chronic kidney diseases: an update systematic review and meta-analysis
  8. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease
  9. Long-Term Effects of Empagliflozin in Patients with Chronic Kidney Disease | New England Journal of Medicine
  10. Prognostic value of neutrophil-to-lymphocyte ratio for the clinical outcomes of chronic kidney diseases: an update systematic review and meta-analysis | BMC Nephrology | Springer Nature Link

Original Source(s)

Inverse association of circulating kallikrein-related peptidase 7 with renal function and mortality risk in patients with chronic kidney disease

  • by Robin Schürfeld, Fabian Baalmann, Ekaterine Baratashvili, Benjamin Sandner, Anette Bachmann, Juliane Weiner, Marleen Würfel, Ralph Wendt, Martin Haussmann, Ingolf Bast, Joachim Beige, Joanna Kosacka, Nora Klöting, Knut Krohn, Toralf Kirsten, Ming-Zhi Zhang, Raymond C. Harris, Berend Isermann, Peter Kovacs, Matthias Blüher, Michael Stumvoll, Anke Tönjes, John T. Heiker, Thomas Ebert

  • July 7, 2026

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