The interplay of maturity-onset diabetes of the young, obesity, uncontrolled hypertension, and cannabinoid hyperemesis in the progression to end-stage renal disease: a case report - Report - MDSpire

The interplay of maturity-onset diabetes of the young, obesity, uncontrolled hypertension, and cannabinoid hyperemesis in the progression to end-stage renal disease: a case report

  • By

  • Neguemadji Ngardig Ngaba

  • Victoria Lovallo

  • Anna ONeil

  • Xegfred Lou T. Quidet

  • Michael Asare

  • Henry Nabeta

  • Shagun Thakur

  • Riddick Osei Agyemang

  • Rayan Alataa

  • Fouad Kaddour Hocine

  • Karla Garcia Rodriguez

  • Abel Akanyijuka

  • Dennis Ansah

  • Akua Amoa

  • Oserefuamen Okobi

  • Shazia Khan

  • Ruchita Kodakandla

  • Sahil Dudhat

  • Shrushti Tanna

  • Del Orbe Eduardo

  • Muhammad Saleem Akhter

  • Rabih Nasr

  • Kalpana Uday

  • Khaja Misbahuddin

  • May 1, 2026

  • 0 min

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Factors Contributing to End-Stage Renal Disease in a Young Patient with MODY

Overview

Revise to include the specific impact of cannabinoid hyperemesis syndrome on renal health.

Background

MODY is a rare genetic form of diabetes that poses significant renal risks, particularly when compounded by obesity and hypertension. Understanding the factors leading to ESRD in young patients is crucial for early intervention and management. This case underscores the importance of recognizing and addressing multiple risk factors in young adults with diabetes.

Data Highlights

ParameterInitial ValueFinal Value
Serum Creatinine (mg/dL)0.910.8
eGFR (mL/min/1.73 m²)115.984.69
HbA1c (%)9.79Range: 6.5–12.1
Microalbumin (mg/L)1.2138
Microalbumin/Creatinine Ratio32931
BMI (kg/m²)22.437.9

Key Findings

Incorporate a point about the effects of chronic cannabis use on kidney function.

Clinical Implications

This case highlights the need for early identification and management of MODY in young patients, particularly those with additional risk factors like obesity and hypertension. Clinicians should consider comprehensive treatment strategies that address both glycemic control and renal protection to mitigate the risk of rapid progression to ESRD.

Conclusion

The rapid advancement to ESRD in this young patient with MODY emphasizes the critical need for integrated management of diabetes and its complications. Early intervention and tailored treatment strategies are essential to improve outcomes in similar cases.

References

  1. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Kidney Hyperfiltration and Mitochondrial Changes Are Associated With eGFR Decline in Young People With Type 1 Diabetes
  2. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Management of Patients with Diabetes Resulting from Exocrine Pancreatic Disorders
  3. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Cross-Site Evaluation of Cardiometabolic Diagnoses in Young Individuals with Congenital Adrenal Hyperplasia: Insights from a PEDSnet Study
  4. KDIGO, 2024 -- KDIGO 2024 CKD Guideline
  5. The Journal of Clinical Endocrinology & Metabolism — Proteomic Analysis of Plasma in Diabetic Kidney Disease Among Asians With Early-Onset Type 2 Diabetes
  6. Get an inside look at cannabinoid hyperemesis syndrome
  7. S U P P L E M E N T TO
  8. HNF1B Transcription Factor: Key Regulator in Renal Physiology and Pathogenesis - PMC

Original Source(s)

The interplay of maturity-onset diabetes of the young, obesity, uncontrolled hypertension, and cannabinoid hyperemesis in the progression to end-stage renal disease: a case report

  • by Neguemadji Ngardig Ngaba, Victoria Lovallo, Anna ONeil, Xegfred Lou T. Quidet, Michael Asare, Henry Nabeta, Shagun Thakur, Riddick Osei Agyemang, Rayan Alataa, Fouad Kaddour Hocine, Karla Garcia Rodriguez, Abel Akanyijuka, Dennis Ansah, Akua Amoa, Oserefuamen Okobi, Shazia Khan, Ruchita Kodakandla, Sahil Dudhat, Shrushti Tanna, Del Orbe Eduardo, Muhammad Saleem Akhter, Rabih Nasr, Kalpana Uday, Khaja Misbahuddin

  • May 1, 2026

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