Clinical Report: Kidney Testing Gets Under the Skin
Overview
A microneedle patch effectively measures a kidney injury biomarker, neutrophil gelatinase-associated lipocalin, in dermal interstitial fluid. The patch demonstrated stability under high temperatures.
Background
Kidney disease is a significant global health issue, with many patients experiencing delayed diagnosis due to limitations in current testing methods. Neutrophil gelatinase-associated lipocalin is a promising biomarker that may rise before traditional markers like serum creatinine.
Data Highlights
| Parameter | Mouse Samples | Human Samples |
|---|---|---|
| Detection Limit | 16 pg/mL | 9 pg/mL |
| Assay Range | 0.1 to 2,000 ng/mL | N/A |
| Fluorescence Retention (Protected) | 94% | N/A |
| Fluorescence Retention (Unprotected) | 7% | N/A |
Key Findings
- The microneedle patch captures neutrophil gelatinase-associated lipocalin from interstitial fluid without reaching blood vessels.
- Neutrophil gelatinase-associated lipocalin levels increased within four hours in a mouse model of acute kidney injury.
- Measurements from interstitial fluid correlated strongly with serum results, despite lower absolute concentrations.
- Protected patches maintained assay sensitivity after temperature cycling and transport.
- The current system requires post-removal processing, indicating it is not a fully self-contained test.
Clinical Implications
The microneedle patch presents a novel approach for kidney biomarker testing. Further studies are necessary to assess the patch's diagnostic performance in patient populations.
Conclusion
This study demonstrates the potential of interstitial fluid as an alternative matrix for kidney biomarker testing.
Related Resources & Content
- Wang et al., Advanced Materials, 2026 -- Metal–Organic Framework‐Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction
- the pathologist — Reflex Testing a No-No for CKD?
- the pathologist — Lessons Learned, with Jeanie Martin
- the pathologist — Bye, Bye ELISA?
- the pathologist — Wasting the Gift of Life?
- KDIGO 2026 AKI-AKD Guideline Public Review Draft
- Reflex Testing a No-No for CKD?
- Lessons Learned, with Jeanie Martin
- Bye, Bye ELISA?
- Neutrophil gelatinase-associated lipocalin in contrast-induced acute kidney injury post cardiac procedure: a systematic review
- The efficacy of novel biomarkers for the early detection and management of acute kidney injury: A systematic review
- International Delphi consensus on acute kidney injury: Foundations for AI-driven digital twin development in critical care nephrology
- Metal–Organic Framework‐Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction - Wang - Advanced Materials - Wiley Online Library
Based on findings from:
Kidney Testing Gets Under the Skin
The Pathologist, 2026.
https://www.thepathologist.com/issues/2026/articles/september/kidney-testing-gets-under-the-skin/
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.
