Associations of CALLY, CLR, and CHR with all-cause mortality in patients receiving maintenance hemodialysis: a two-center retrospective cohort study - Report - MDSpire
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Associations of CALLY, CLR, and CHR with all-cause mortality in patients receiving maintenance hemodialysis: a two-center retrospective cohort study
Clinical Report: Links Between CALLY, CLR, and CHR Indices and Overall Mortality
Overview
This study investigates the relationship between inflammation-related indices and all-cause mortality in patients undergoing maintenance hemodialysis (MHD).
Background
Patients on maintenance hemodialysis are at a significantly elevated risk of mortality, influenced by chronic inflammation and other biological disturbances. This study evaluates the CALLY, CLR, and CHR indices as potential markers for mortality risk in MHD patients.
Data Highlights
Index
Hazard Ratio (HR)
95% Confidence Interval (CI)
P-value
ln CALLY
0.85
0.77-0.94
0.002
ln CLR
1.19
1.06-1.33
0.003
ln CHR
1.18
1.07-1.31
0.002
Key Findings
ln CALLY was associated with a lower risk of all-cause mortality (HR 0.85).
ln CLR was linked to a higher risk of all-cause mortality (HR 1.19).
ln CHR also indicated a higher risk of mortality (HR 1.18).
Significant survival differences were observed across tertiles of the indices.
3-year AUCs for ln CALLY, ln CLR, and ln CHR were 0.603, 0.598, and 0.563, respectively.
Clinical Implications
The CALLY, CLR, and CHR indices may serve as accessible tools for initial prognostic risk stratification in patients undergoing MHD. Clinicians should consider these indices when assessing mortality risk in this population.
Conclusion
The study highlights the independent associations of ln CALLY, ln CLR, and ln CHR with all-cause mortality in MHD patients.
