Investigating the association between low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and the risk of carotid artery plaque in patients with first-ever ischemic stroke based on different glucose metabolic conditions - Report - MDSpire
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Investigating the association between low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and the risk of carotid artery plaque in patients with first-ever ischemic stroke based on different glucose metabolic conditions
Clinical Report: LDL/HDL Cholesterol Ratio and Carotid Plaque Risk in Stroke Patients
Overview
This study examines the association between the LDL-C/HDL-C ratio and carotid plaque risk in first-ever ischemic stroke patients, highlighting the stronger correlation in prediabetic individuals.
Background
Atherosclerosis is a significant underlying cause of ischemic stroke (IS), with dyslipidemia and impaired glucose metabolism being critical risk factors.
Data Highlights
Parameter
Findings
Participants with Carotid Plaque
9,469 (77.8%)
LDL-C/HDL-C Association in Pre-DM
OR: 1.233 (95% CI: 1.093–1.391)
LDL-C/HDL-C Association in DM
OR: 1.178 (95% CI: 1.074–1.293)
HbA1c Contribution
11.5%
FPG Contribution
10.5%
Key Findings
LDL-C/HDL-C ratio has a stronger association with carotid plaque risk than other lipid parameters.
The association is significantly stronger in patients with prediabetes compared to those with diabetes or normal glucose regulation.
HbA1c and FPG account for 11.5% and 10.5% of the LDL-C/HDL-C and carotid plaque risk association, respectively.
Elevated LDL-C/HDL-C is linked to carotid atherosclerosis in first-ever ischemic stroke patients.
Clinical Implications
The findings indicate that monitoring the LDL-C/HDL-C ratio could be beneficial in assessing carotid plaque risk, particularly in patients with prediabetes.
Conclusion
Elevated LDL-C/HDL-C is significantly associated with carotid atherosclerosis in ischemic stroke patients, especially in those with prediabetes.
