Anxiety symptoms following conception through assisted reproductive technology: a systematic review - Report - MDSpire

Anxiety Symptoms After Conception via Assisted Reproductive Technology: A Comprehensive Review

  • By

  • Nicole L. Davies

  • Lauren Carson

  • Roxanne C. Keynejad

  • July 20, 2026

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Clinical Report: Anxiety Symptoms After Conception via Assisted Reproductive Technology

Overview

This comprehensive review examines the prevalence and mean anxiety symptom scores among women who conceived through assisted reproductive technology (ART) compared to those who conceived spontaneously. Findings indicate varying results regarding anxiety levels, particularly during late pregnancy and postpartum, as reported in the included studies.

Background

The increasing use of assisted reproductive technology (ART) raises concerns about the psychological outcomes for women undergoing these procedures. ART is associated with various physical and psychological risks, including heightened anxiety, as noted in several studies. Understanding these psychological sequelae is crucial for improving care and support for women experiencing fertility challenges.

Data Highlights

The review included twenty studies, comprising cohort (n=15), case-control (n=1), and cross-sectional (n=4) designs, with varying findings regarding anxiety symptoms in ART versus spontaneous conception groups.

Key Findings

  • Most studies reported non-significant differences in anxiety symptoms during the first and second trimesters between ART and spontaneous conception groups.
  • In the third trimester, four studies indicated higher anxiety levels in the ART group, while nine showed no significant differences.
  • Postnatal anxiety findings were mixed, with two studies reporting higher anxiety in the ART group and four showing no significant differences.
  • Some studies noted elevated pregnancy-specific anxiety symptoms in the ART group, particularly in late pregnancy.

Clinical Implications

Healthcare providers should be aware of the potential for increased anxiety symptoms in women undergoing ART, especially during late pregnancy and postpartum, as indicated by the reviewed studies.

Conclusion

The review highlights the complexity of anxiety symptoms following ART, with findings that vary across studies, necessitating further research to clarify the psychological impact on women during and after pregnancy.

Related Resources & Content

  1. BMC Pregnancy and Childbirth, 2024 -- Live births after low initial β-hCG in IVF cycles: a retrospective cohort study
  2. BMC Pregnancy and Childbirth, 2024 -- Associated factors for early pregnancy-related anxiety: a multicenter cross-sectional study in Japan
  3. conexiant, 2024 -- IVF Babies and Allergy Risk: New Data
  4. BMC Pregnancy and Childbirth, 2024 -- A study on the correlation among sleep quality in pregnant women, type 2 diabetes risk scores based on FINDRISC, and pregnancy-related anxiety
  5. CLINICAL PRACTICE GUIDELINE, 2024 -- Screening and Diagnosis of Mental Health Conditions During Pregnancy and Postpartum
  6. Risk of Mood and Anxiety Disorders in the Postpartum Period Following Assisted Reproduction: A Retrospective Cohort Study - PMC, 2024
  7. CLINICAL PRACTICE GUIDELINE
  8. Risk of Mood and Anxiety Disorders in the Postpartum Period Following Assisted Reproduction: A Retrospective Cohort Study - PMC

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